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The eye as a window to the brain1836inferior segment, as compared to controls. In addition, we found negative correlations of age with FD and RNFL thickness in the global, temporal inferior and temporal superior segments in adults with 22q11.2DS, that were not found in controls.Retinal vascular morphometric abnormalitiesIncreased retinal vascular FD and tortuosity in the peripapillary region have been also reported in patients with community-based schizophrenia, 16, 20a psychiatric disorder that affects about 1 in 4 patients with 22q11.2DS.5However, findings in this new research area are inconsistent. For example, lower macular FD has also been found in an independent sample of patients with schizophrenia.17 Similarly, both smaller and wider arterioles, and wider venules, have been reported in patients with schizophrenia.12, 16, 17 Wagner et al. recently discussed possible explanations for the inconsistent findings between studies, like the complex relationship between disease duration, retinovascular parameters, age, and comorbidities such as diabetes and hypertension.17 Another contributing factor in this regard might be the retinal region studied, i.e., macular or peripapillary region, in the concerning studies. The finding of a negative correlation of FD with age in adults with 22q11.2DS is consistent with studies in much older adults in the general population with (mild) cognitive impairment and Alzheimer’s disease.13, 28This raises the question to what extent this finding indicates premature neurodegenerative processes, that may underly cognitive decline and earlyonset Parkinson’s disease in 22q11.2DS.6, 8 Interesting in this context is that studies in a mouse model of aging have shown a negative relationship in retinal branching with age.29, 30Retinal nerve fiber layer thicknessThicker RNFL of the nasal, and a trend for thinner RNFL in the nasal inferior, segments in 22q11.2DS were found compared to controls. Findings from studies examining RNFL in idiopathic schizophrenia spectrum disorders have been inconsistent. Some studies found the RNFL to be significantly reduced, specifically in the nasal and superior segments,15, 31 but not all.17, 32, 33