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Chapter 6186over time, and to investigate the effects of comorbid conditions such as refractive errors, diabetes mellitus and blood pressure,17, 27, 56-58 and effects of medications. It will also have to become clear to what extent abnormal retinal morphological findings are biomarkers of 22q11.2DS associated disease processes, or are merely manifestations of 22q11.2DS in themselves.ConclusionIn conclusion, this exploratory study identified several retinovascular and retinoneural abnormalities in adults with 22q11.2DS compared to controls. The results of this study support future research that focus on retinal FD, tortuosity and RNFL thickness as potential biomarkers for psychotic and (early) neurodegenerative disorders in 22q11.2DS.FundingThis work was supported financially by Stichting Wetenschappelijk Onderzoek, ‘s Heeren Loo under grant number 2210100. The funder had no role in the design and conduct of the study, preparation of the review, or approval of the manuscript.Acknowledgments The authors thank the students and colleagues at Maastricht University and ‘s Heeren Loo for their contributions to this study, in particular Marjan Drukker (Maastricht University) for review and critique of the statistical analysis. Agnies van Eeghen is member of European Reference Network ITHACA.DisclosuresThe authors report there are no competing interests to declare.Data availabilityThe data that support the findings of this study are available on request from the corresponding author, E.B. The data are not publicly available due to their containing information that could compromise the privacy of research participants.