Page 182 - Demo

Chapter 6180ResultsDemographics Demographic characteristics are presented in Table 1. For the study of retinal vessel morphology, 49 adults with 22q11.2DS were included. Of 60 potential controls, 2 were excluded from participation due to a retinal disease, and 1 was excluded from analyses due to technical problems. OCT data were available for 41 adults with 22q11.2DS, 16 with data on macular thickness, and 40 controls. By design, no statistically significant differences were found in mean age or sex distribution between adults with 22q11.2DS and controls.Retinal vessel morphologyTable 2 shows the results for vascular parameter measurements. No differences were found in CRAE or CRVE between adults with 22q11.2DS and controls. However, adults with 22q11.2DS had significantly higher FD and vascular tortuosity compared to controls, with large effect sizes.Retinal layer thicknessResults for peripapillary RNFL and macular thickness are shown in Table 2. Significant between-group differences were found with increased nasal RNFL thickness in the group of adults with 22q11.2DS as compared to controls. A trend for thinner RNFL of the nasal inferior segment was observed in adults with 22q11.2DS. No differences in macular thickness were found between adults with 22q11.2DS and controls.Optometric variables in relation to ageCorrelations of age with retinal vessel morphology and retinal layer thickness are shown in Table 3. There were no significant correlations of age with CRAE or CRVE in either adults with 22q11.2DS or controls. A moderate negative correlation was found of age with FD in adults with 22q11.2DS but not in controls. No significant correlations were found of age with tortuosity in adults with 22q11.2DS or controls.