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Chapter 6182Table 3. Blood vessel morphology and retinal layer thickness in relation to age.22q11.2DSN=49ControlsN=57Blood vessel morphology r aP r aPCRAE, μmCRVE, μmFDTortuosity0.030.01- 0.570.040.850.96<0.0010.780.14- 0.04- 0.07- 0.080.320.760.600.5622q11.2DS N=41ControlsN=40Peripapillary RNFL, μm r aP r aPGlobal b - 0.42 0.007 - 0.07 0.68 Nasal superior Nasal Nasal inferior Temporal inferior Temporal Temporal superior- 0.22- 0.25- 0.10- 0.43- 0.19- 0.320.170.110.530.0050.220.04- 0.130.02- 0.01- 0.010.03- 0.160.410.890.940.950.870.3122q11.2DS N=16ControlsN=40Macula, μm r aP r aP Fovea Parafovea Temporal Superior Nasal Inferior Perifovea Temporal Superior Nasal Inferior- 0.190.02- 0.070.13- 0.18- 0.41- 0.50- 0.06- 0.450.480.960.790.630.520.12<0.050.820.080.21- 0.06- 0.28- 0.10- 0.07- 0.25- 0.38- 0.25- 0.070.200.720.080.540.680.130.020.130.68a Pearson correlation coefficient.b The global RNFL thickness represents the average thickness of the six subsections. Bold font indicates statistical significance.22q11.2DS=22q11.2 deletion syndrome, CRAE=central retinal artery equivalent, CRVE=central retinal vein equivalent, FD=fractal dimension, RNFL=retinal nerve fiber layer.DiscussionTo the best of our knowledge, this is the first study that systematically assessed retinal blood vessel morphology and retinal layer thickness quantitatively in individuals with 22q11.2DS. Confirming the previously reported increased prevalence of vascular tortuosity,27 we also found that adults with 22q11.2DS had increased retinal vascular FD and RNFL thickness of the nasal segment, and a trend for thinner RNFL in the nasal