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Alveolar iodine tampon packing reduces postoperative morbidity after third molar surgery674of these data, the analysis was repeated using the Wilcoxon signed-rank test, which resulted in identical conclusions. Figure 1: Mean number of prescribed analgesics used on postoperative days 1-7.Mean number of prescribed analgesics used on postoperative days 1-7.Iodine tampon Monoject® syringeSignificantly fewer analgesics were used after the iodine tampon intervention compared to the Monoject®-syringe (all p < .01). Data are presented as mean + 1.96 SE (=95% confidence interval). Identical conclusions were found when the analysis was repeated using the Wilcoxon signed-rank test, given the skewed distribution of the data.Effect of the alveolar iodine tampon on the first postoperative weekTable 2 provides information on a number of variables. The first postoperative week was superior in all aspects for extraction using the iodine tampon relative to extraction without the tampon. Generally, one can compare two dependent proportions using the McNemar test. However, given the eight different aspects in Table 2, 7 days would require 56 McNemar tests. Rather than knowing whether a particular aspect differs statistically on a particular day, the clinical relevance is more important and seems quite high which can be illustrated by a couple of examples. For example, on day 7 after extraction using the iodine tampon, 33 patients (61.1%) reported no problems at all versus 15 patients (27.8%) following extraction using wound closure and Monoject® syringe use. On day 4 after extraction using the iodine tampon, 25 patients (46.3%) used the prescribed pain medication versus 39 patients (72.2%) following extraction using wound closure and Monoject® rinsing. Similar results were found for limited mouth opening on day 4 (27 versus 45), limited chewing ability on day 4 (28 versus 41), and pain on day 6 (10 versus 37). For the first postoperative days, patients were asked to report the number of hours they spent using an ice pack. The paired samples t-test showed no significant difference between the intervention and control extraction (t (53) = 1.31, p = .19; mean 5.5 h, range 0-15 h).