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Chapter 61685 or CBCL/6-18. Assumptions were tested, including normality, linearity, homoscedasticity, and presence of significant outliers. A moderately strong correlation (Pearson’s or Spearman’s r > 0.5) was expected between 1) the TSC-PROM physical functions domain score and the SF-36 physical component score, 2) the TSC-PROM mental functions domain score and the SF-36 mental component score, and 3) the TSC-PROM mental functions domain score and the total ASR score or CBCL scores. Also, it was expected that TSC-PROM domains are associated with TSC-PROM VAS scores (weak correlations). Construct validity was considered sufficient if 75% of the hypotheses were met.Another subtype of construct validity is discriminative validity, which refers to the degree that measures of constructs that theoretically should not be highly related to each other are in fact not found to be highly correlated to each other. To assess discriminative validity, analyses were performed using group dichotomization or categorization. A priori hypotheses were defined including 1) patients with TSC2 mutations will show lower TSCPROM scores on the physical domain, mental domain, and TSC-PROM HRQoL VAS compared to patients with a TSC1 mutation60-62, 2) patients who reported a drastic life event in the past year will show a lower score on the mental functions domain, 3) patients with a higher number of involved organ systems will show lower scores on the HRQoL VAS27, and 4) patients with the presence of psychiatric diagnoses will show lower TSC-PROM scores on the mental functions domain, activities and participation domain, and HRQoL VAS27. Assumptions were tested, including normality and homogeneity of variances. Independent samples t-tests or Mann-Whitney U-tests were performed. Effect sizes were calculated via r = z/√N.Annelieke Muller sHL.indd 168 14-11-2023 09:07