Page 122 - Migraine, the heart and the brain

Chapter 7
Cerebellar tests
Purdue pegboard task. A total of 282 participants (111 MA, 89 MO, and 82 controls) underwent Purdue pegboard investigation. There were no differences between the three groups on the assembly task or any of the other outcome measures (Table 2). The 20 individuals with a cerebellar ischaemic lesion performed signi cantly worse on most pegboard tasks (assembly task 5.9 vs 7.3, p= 0.002; number of pegs with right hand 12.4 vs 13.6 in non-infarct group, p= 0.03; and number of pegs with both hands 9.4 vs 10.8, p= 0.001) (Supplemental table). Among migraine patients the 17 with cerebellar ischaemic lesions on average performed worse than the 183 migraine patients without such lesions (assembly task 5.9 vs 7.3, respectively, p=0.005; number of pegs with right hand 11.8 vs 13.5, p=0.003; and number of pegs with both hands 9.5 vs 10.9, p= 0.006) (Supplemental table and Table 2). Participants with FHM1 (n =12) performed signi cantly worse on the assembly score (p= 0.04) and right-handed tasks (p= 0.03), but not on the other pegboard scores (Table 2).
Table 2. Participant characteristics and outcomes of Purdue pegboard investigation.
Controls (n=82)
55 (7.5) 72% 91% NA
4%
NA NA 5%
7.3 (1.9) 13.7 (2.3) 13.2 (2.2) 10.5 (1.8) 37.5 (5.4)
MA (n=111)
57 (8.1)
72%
93%
14 (20; 1–170)
10%
5% 14% 8%
6.8 (1.9) 13.6 (2.1) 13.3(2.2) 10.8 (2.0) 37.5 (5.5)
MO (n=89)
58 (7.5)
71%
100%
19 (19; 2–105)
7%
1% 8% 10%
7.3 (1.9) 13.1 (2.3) 13.1 (2.4) 10.8 (1.9) 37.0 (5.7)
p value three groups
FHM1 (n=12)
42 (13.3) 67% 100%
7 (14; 1–52)
NA
25% 0% 8%
6.0 (1.3) 12.0 (2.0) 12.8 (2.3) 10.5 (2.4) 35.0 (4.9)
p value four groups
Participant characteristics Mean age (SD)
Female gender
Right handedness
Mean attacks per year (SD; range) Cerebellar lesion MRI Medication:
Migraine prophylaxis
Triptans
Sedatives
Outcomes Purdue pegboard Assembly task
Right-handed task Left-handed task Both-handed task Sum score
0.1 0.1 0.9 0.6 0.8
a 0.04a
0.03 0.9 0.8 0.5
Tabled values represent the group means and standard deviations (SD), except for the variable gender, right handedness, medication and cerebellar lesions. Handedness data were taken from 278 +12 participants; MRI participants with pegboard from 275.Pegboard tasks are displayed as mean pegs during 30 seconds (SD).Range right-handed task covers 5–19 pegs, range sum score covers 16–50 pegs, and range assembly task 2–12 pegs. aBonferroni post-hoc analysis all<0.05 for FHM1 vs controls, FHM1 vs MAand FHM1 vs MO.
MA: migraine with aura; MO: migraine without aura; FHM1: familial hemiplegic migrainetype 1; MRI: magnetic resonance imaging; NA: not applicable; SD: standard deviation.
120