Page 123 - Migraine, the heart and the brain

Table 3. Participant characteristics and outcomes of block design test.
Cerebellar function and ischemic brain lesions in migraine
Block-design test. A total of 202/282 (72%) participants (82 MA, 62 MO, and 58 controls) underwent the block-design test. The scaled score (primary endpoint) as well as the raw score and percentage within the highest tertile of scaled score (secondary endpoints) were not signi cantly different between migraine patients with or without aura and controls (Table 3). Participants with cerebellar ischaemic lesions (n= 9) did not perform worse than those without (Supplemental table). Participants with FMH1 (n=12) obtained signi cantly lower scores on the block-design test than the other three study groups. None of the participants with FHM1 was in the highest tertile of scaled scores (Table 3).
Controls (n= 58)
55 (7.3) 64% 91% NA
2%
NA NA 2%
9.8 (3.2) 11 (19%) 30.3 (14.6)
MA (n=82)
57 (8.2)
70%
95%
17 (26; 1–170)
8%
0% 11% 10%
10.7 (3.6) 27 (33%) 33.5 (15.9)
MO (n=62)
58 (7.4)
76%
94%
17 (17; 2–105)
3%
0% 8% 8%
9.7 (3.3) 15 (24%) 29.5 (13.9)
p value three groups
FHM1 (n=12)
42 (13.3) 67% 100%
7 (14; 1–52)
NA
25% 0% 8%
4.0 (3.0) 0 (0%) 13.4 (11.3)
p value four groups
Participant characteristics Mean age (SD)
Female gender Right-handedness (%) Mean attacks per year (SD; range)
Cerebellar lesion MRI Medication: Migraine prophylaxis Triptans
Sedatives
Outcomes block design test Mean scaled score (SD)
Scaled score, high Mean raw score (SD)
0.2 0.2 0.2
a <0.001
0.047 a <0.001
7
Handedness known for 198 + 12 participants. Neurological examination for 200+12 participants. MRI for 199 participants. High education de ned as university of professional education or higher; block-design test scaled score was recoded in tertiles (low, medium, high), low 4–7, medium 8–12, high 13–19; analysis of variance (ANOVA) post hoc aBonferroni all<0.001.
MA: migraine with aura; MO: migraine without aura; FHM1: familial hemiplegic migrainetype 1; MRI: magnetic resonance imaging; NA: not applicable; SD: standard deviation.
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