Page 121 - Migraine, the heart and the brain

Table 1. Characteristics and physical examination.
Cerebellar function and ischemic brain lesions in migraine
Characteristics
Mean age (SD)
Female gender
Right-handedness
Mean attacks per year (SD; range) Cerebellar lesion on MRI Medication:
Migraine prophylaxis
Triptans
Sedatives
Physical examination Limb hypermetria/ataxia
Dysdiadochokinesis Hypermetric eye movements
Controls (n=82)
55 (7.5) 72% 91% Na 4%
NA NA 5%
4% 3% 3%
MA (n=111)
57 (8.1)
72%
93%
14 (20; 1–170) 10%
5% 14% 8%
2% 4% 2%
MO (n=89)
58 (7.5)
71%
94%
19 (19; 2–105) 7%
1% 8% 10%
3% 2% 1%
FHM1 (n=13)
42 (13.3) 67% 100%
7 (14; 1–52) 0%
23% 8% 8%
15% 8% 0%
Physical examination is available in 282 + 12. MRI is available in 275 +2 participants. MA: migraine with aura; MO: migraine without aura; FHM1: familial hemiplegic migraine type 1; MRI: magnetic resonance imaging; NA: not applicable; SD: standard deviation.
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Figure 1. (a) Three examples of cerebellar infarcts in patients with migraine with aura. In the upper row T2- weighted images (infarcts appear as hyperintense parenchymal defects, indicated with arrowheads) and in the lower row corresponding FLAIR images. From left to right: female, 66 years old, with a small infarct in the right cerebellar hemisphere; male, 62 years old, with a medium-sized infarct in the right cerebellar hemisphere; and male, 54 years old, with multiple large infarcts in the left paravermal region. (b) MRI images from a 40-year-old male FHM1 patient, without cerebellar infarct or evidence of cerebellar or vermian atrophy; in the supratentorial white matter some nonspeci c white-matter hyperintense lesions (arrowhead) are present (left image: transverse T2weighted image; middle image: coronal T1-weighted image; right image: transverse FLAIR image). FLAIR: fluid-attenuated inversion recovery; MRI: magnetic resonance imaging; FHM1: familial hemiplegic migraine type 1.
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