Page 143 - Functional impairment and cues for rehabilitation of head and neck cancer patients -

Appendix 10 Functional outcomes at t1 and t2 stratified by HPV status. P values shown for multivariable regression adjusted for T and N classification, treatment and modified diet at t0.
t1
t2
HPV -
n = 31
HPV +
n = 64
Adjusted p value
HPV -
n = 18
HPV +
n = 51
Adjusted p value
Swallowing outcomes
Trismus outcomes
19 (61) 43 (68) .206
12 (39) 20 (32) 01
21 (0-77)
8 (0-52) .492
9 (38)
15 (63)
7 24
26 (65) .868 14 (35)
Mouth opening in mm
Median (range)
Trismus
Perceived trismus
No
Yes Unknown No
Yes Unknown
5
Speech and voice outcomes
42 (18-54)
45 (16-63) .627
23 (77)
7 (23)
19
25 (86) 40 (80) .074
4 (14) 10 (20) 2 14
43 (78) .611 12 (22)
Vowel Space Area (%)
Median (range) Vowel Space No
Area < 80%
SHI total score (0–120)
Median (range)
SHI ≥ 6 No
Yes Unknown
NB: Not all percentages sum up exactly to 100% due to rounding.
Yes Unknown
77 (58-100)
82 (49-107) .913
13 (48)
14 (52) 49
4 (0-61)
12 (60) 8 (40) 11
3 (0-52) .896
25 (69) .995 11 (31)
28
43 (78) .645 12 (22)
Abbreviations: FOIS = functional oral intake scale, HPV = human papillomavirus, SHI = speech handicap index, t1 = six months after treatment, t2 = twelve months after treatment.
Functional outcomes after (C)RT for OPC
Modified diet No (FOIS < 7)
Yes
Unknown
SWAL-QOL total score (0–100) Median (range)
SWAL-QOL No
13 (72)
5 (28)
0
14 (0-32)
8 (62) 5 (39) 5
45 (27-53)
15 (88) 2 (12) 1
15 (94)
1 (6) 2
77 (51-102)
7 (44) 9 (56)
2
1 (0-10)
11 (85) 2 (15) 5
39 (77) .460
12 (24)
0
5 (0-43) .652
29 (76) .292 9 (24)
13
43 (10-64) .046
38 (76) .086 12 (24)
1
39 (87) .996
6 (13) 6
76 (53-112) .528
16 (41) .463 23 (59)
12
0 (0-40) .151
24 (92) .325 2 (8)
25
≥ 14
Yes Unknown
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