Page 141 - Functional impairment and cues for rehabilitation of head and neck cancer patients -

Appendix 8 Baseline characteristics by vowel space area below 80% at t1 and univariable analysis.
Female Age at baseline Median (range)
9 (27)
60 (39-75)
1.9 (0.5-7.0) .350 1.0 (1.0-1.1) .756 .501
ACE-27
BMI Median (range) SMM Median (range) Sarcopenia
Tumor site
T classification
HPV status
2 (6)
25 (18-33) 45 (30-54)
1.1 (0.1-14.0) .917 1.0 (0.8-1.1) .473 1.0 (0.9-1.0) .345
Treatment modality
1.1 (0.3-3.6) .852
.108
5.1 (0.8-30.2) .075
15 (52) 4
Pretreatment VSA < 80%
No
Yes Unknown
2.7 (0.8-8.8) .093 4.6 (1.2-16.9) .023
0 1 2 3
No Yes
Base of tongue Tonsil
Other
T1 T2 T3 T4
Negative Positive Unknown
RT
RT + cetuximab RT + cisplatin
21 (64) 1.0
Functional outcomes after (C)RT for OPC
VSA > 80% at t1
n = 24
VSA < 80% t1 n = 33
Univariable logistic regression analysis
OR (95%CI)
P value
Gender
Male
20 (83)
4 (17)
61 (44-75)
12 (50)
11 (46)
0 (0)
1 (4)
26 (20-44) 46 (32-64)
18 (75) 6 (25)
8 (33) 12 (50) 4 (17)
7 (29) 7 (29) 6 (25) 4 (17)
7 (30) 16 (70) 1
13 (54) 2 (8)
9 (38)
17 (77) 4 (24) 3
24 (73) 1.0
8 (24)
2 (6) NA
20 (61) 1.0
13 (39)
14 (42) 1.0
.258 5 .756
15 (46) 4 (12)
0.7 (0.2-2.3) .568 0.6 (0.1-2.9) .502 .963
8 (24) 1.0
10 (30) 8 (24) 7 (21)
1.3 (0.3-5.1) .755 1.2 (0.3-5.1) .837 1.5 (0.3-7.5) .600
9 (28) 1.0
23 (72) 1
9 (27) 1.0 7 (21)
17 (52)
14 (48) 1.0
0.4 (0.1-1.3) .136
2.0 (0.6-6.2)
NB: Not all percentages sum up exactly to 100% due to rounding.
Abbreviations: BMI = body mass index, CI = confidence interval, HPV = human papilloma virus, FOIS = functional oral intake scale, OR = odds ratio, other = soft palate, uvula, oropharyngeal wall, vallecula or pharyngeal arch, RT = radiotherapy, sarcopenia = SMM below 43.2 cm2/m2, SMM = skeletal muscle mass, VSA = vowel space area.
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