Page 49 - Pro-active Management of Women’s Health after Cardiometabolic Complicated Pregnancies

2.2 Associations between phenotypes of preeclampsia and thrombophilia| 47
preeclampsia: IUGR and HELLP. The 4 subgroups were defined as IUGR-HELLP-, IUGR+, HELLP-, IUGR-, HELLP+ and IUGR+HELLP+. For the above mentioned 11 thrombophilia factors we used the continuous data for the analysis. If more than one sample was available, we used the result that was least abnormal.
Associations of thrombophilia factors with the different phenotypes of preeclampsia and the factor analysis were done with the statistical software package IBM SPSS Statistics Version 20 (IBM Corporation, 2011) using X2-tests with continuity correction. Missing values were excluded for the analysis. A two- sided p-value of less than 0.05 was considered statistical significant.
RESULTS
A total of 844 women were tested for thrombophilia. The general characteristics of these patients are summarized in table 2.2.1. Placental histology was available for 545 women.
Table 2.2.2 shows the preeclampsia phenotypes and the prevalence of the thrombophilia. Overall 29% of the women had one or more abnormal thrombophilia results. Severe preeclampsia was significantly associated with a higher presence of one or more thrombophilia result (p=0.01) and with more prevalent Protein-S deficiency (p=0.01) compared to mild preeclampsia.
IUGR was significantly associated with a higher presence of one or more thrombophilia factors (p<0.01) and more prevalent anti-phospholipid antibodies (p<0.01) compared to normal grown fetuses. Early onset preeclampsia (gestational age <34weeks at delivery) was significantly associated with a higher presence of one or more thrombophilia factors (p<0.01) and more prevalent anti-phospholipid antibodies (p=0.01) compared to late preeclampsia (gestational age ≥ 34weeks at delivery). Increased placental infarction (≥ 10% of