Page 48 - Pro-active Management of Women’s Health after Cardiometabolic Complicated Pregnancies

46 | Part 2 Cardiovascular Health
confirmed a patient was considered positive for this coagulation abnormality. If a patient with an initial abnormal test result was not retested, the presence or absence of this coagulation abnormality was reported as missing.
The percentage of placental infarction was estimated by combining macroscopy and microscopy of the placenta. Placental weight was measured without umbilical cord and membranes. The percentile was calculated according to a previous study102.
The thrombophilia factors were tested for associations. If more than one thrombophilia measurements were missing, the category ‘one or more thrombophilia’ was also marked as missing. The phenotypes of preeclampsia tested for associations were: HELLP syndrome, IUGR, early (<34 weeks) or late onset (≥ 34 weeks), minimal (<10%) versus extensive (≥10%) placental infarction and normal (>5th centile) versus low (≤5th centile) placental weight.
Furthermore, we did a factor analysis with a fixed 2-axis model. For this we defined 4 different subgroups with the 2 most important phenotypes of
Table 2.2.1. General characteristics (N=844); values are presented as % of the study population (n) or as median (range).
Maternal age at conception (years)
Nulliparous
Gestational age at delivery (weeks)
Gestational age at onset of preeclampsia (weeks) Severe preeclampsia
HELLP syndrome
Intra uterine growth restriction Eclampsia
Placental abruption
Birth weight (grams)
Birth weight percentile
Fetal death
Information on placental histology Placental weight (grams)
Placental weight percentile Placental infarction (%)
29 (17-43) 74% (627)
31 (27-40)
29 (15-40) 91% (768)
49% (413)
61% (512)
3% (28)
4% (30)
1090 (275-3720) 3.1 (0-100) 14% (116)
65% (545) 235 (45-700) 6.5 (0-100) 5 (0-90)