Page 51 - Pro-active Management of Women’s Health after Cardiometabolic Complicated Pregnancies

2.2 Associations between phenotypes of preeclampsia and thrombophilia| 49 Table 2.2.3. Odds-ratios for phenotypes of preeclampsia, grey cells flag p < 0.05
Factor
One or more thrombophilia factor Anti-phospholipid antibodies Protein-C deficiency
Protein-S deficiency
APC Resistance (FVL excluded) Hyperhomocysteineamia
Factor V Leiden (heterozygous) Prothrombin gene mutation (heterozygous)
One or more thrombophilia factor Anti-phospholipid antibodies Protein-C deficiency
Protein-S deficiency
APC Resistance (FVL excluded) Hyperhomocysteineamia
Factor V Leiden (heterozygous) Prothrombin gene mutation (heterozygous)
One or more thrombophilia factor Anti-phospholipid antibodies Protein-C deficiency
Protein-S deficiency
APC Resistance (FVL excluded) Hyperhomocysteineamia
Factor V Leiden (heterozygous) Prothrombin gene mutation (heterozygous) Controls: no IUGR and no HELLP
Model 1 Model 2 Model 3 IUGR without HELLP (cases = 241, controls = 190)
2,02 (1,26-3,22)
1,87 (1,16-3,01)
1,79 (1,05-3,05)
1,6 (0,7-3,67) 0,85 (0,05-13,61) 2,21 (1,11-4,39) 1,9 (0,71-5,07) 1,38 (0,71-2,68) 1,58 (0,62-4,03) 0,65 (0,17-2,47)
1,43 (0,61-3,32) 0,98 (0,06-16,26) 2,01 (1-4,04) 2,02 (0,74-5,53) 1,46 (0,74-2,86) 1,45 (0,56-3,77) 0,53 (0,13-2,13)
0,99 (0,39-2,53) 2,93 (0,15-58) 1,87 (0,86-4,03) 2,37 (0,8-7,01) 1,62 (0,75-3,49) 1,16 (0,41-3,31) 0,42 (0,09-1,92)
HELLP without IUGR (cases = 138, controls = 190)
1,54 (0,91-2,61) 0,92 (0,32-2,66) 2,81 (0,25-31,35) 2,06 (0,97-4,34) 2,11 (0,73-6,12) 1,5 (0,7-3,18) 0,77 (0,22-2,7) 1,09 (0,29-4,14)
1,41 (0,82-2,41) 0,98 (0,33-2,88) 2,43 (0,22-27,35) 1,81 (0,85-3,87) 1,89 (0,64-5,55) 1,58 (0,73-3,4) 0,68 (0,19-2,41) 1,01 (0,26-3,89)
1,39 (0,8-2,41) 0,82 (0,27-2,44) 2,22 (0,18-27,15) 1,97 (0,89-4,33) 1,81 (0,61-5,41) 1,68 (0,77-3,67) 0,51 (0,14-1,85) 0,98 (0,25-3,87)
HELLP and IUGR (cases = 271, controls = 190)
2,21 (1,41-3,47)
2,05 (1,29-3,26)
2 (1,15-3,45)
2,16 (0,98-4,73) 1,45 (0,13-16,13) 2,17 (1,12-4,23) 1,59 (0,6-4,24) 1,63 (0,88-3,03) 1,47 (0,58-3,71) 1,76 (0,61-5,07)
2,1 (0,95-4,67) 1,4 (0,12-15,99) 1,67 (0,84-3,34) 1,76 (0,64-4,83) 1,79 (0,95-3,36) 1,41 (0,55-3,65) 1,63 (0,55-4,79)
1,15 (0,46-2,88) 3,11 (0,11-91,97) 1,92 (0,85-4,35) 2,81 (0,89-8,89) 1,9 (0,91-3,97) 0,84 (0,28-2,5) 1,51 (0,43-5,25)
Model 1: crude estimates
Model 2: adjusted for maternal age at conception and nulliparous
Model 3: model 2 + adjusted for gestational age at onset of preeclampsia