Page 106 - Pro-active Management of Women’s Health after Cardiometabolic Complicated Pregnancies

104 | Part 3 Lifestyle intervention
Table 3.2.2. Calculated odds-ratios (OR) for cardiovascular disease (CVD).
Risk prediction model
OR for CVD after preeclampsia (preeclampsia vs. control)
OR for CVD of hypothetical lifestyle interventions after preeclampsia (before vs. after)
Ischemic Heart Disease
MONICA37 1.23 PROCAM34 1.09 SCORE35 1.14
Stroke
EuroStroke38 1.17
Ischemic Heart Disease and stroke
CUORE36 1.31 Reynolds Risk Score40 1.42 Framingham 30y-BMI39 1.27 Framingham 30y-Lipids39 1.25
(1.19-1.36) 0.92 (0.98-1.23) 0.94 (1.02-1.30) 0.87
(1.06-1.29) 0.96
(1.16-1.57) 0.88 (1.25-1.71) 0.87 (1.10-1.46) 0.95 (1.10-1.49) 0.87
OR
(Q1-Q3*)
OR
(Q1-Q3*)
(0.84-0.96) (0.88-0.97) (0.81-0.96)
(0.91-0.98)
(0.85-0.99) (0.80-0.98) (0.87-0.98) (0.83-0.98)
articles were included. Screening the references of these articles resulted in an additional 3 studies. Table 3.2.3 lists all 16 studies included in the analysis categorised by cardiovascular risk factor. Of each cardiovascular risk factor the median and interquartile range of the difference between former preeclamptic women and women without a former preeclamptic pregnancy is shown in table 3.2.1.
The calculated odds-ratios based on these values are shown in table 3.2.2. For ischaemic heart disease a median odds-ratio of 1.14 was calculated based on the differences of cardiovascular risk factors after a history of preeclampsia compared to a healthy pregnancy. Dividing the observed odds-ratio of 2.16 with this calculated odd-ratio of 1.14, an odds-ratio of 1.89 (1.76-1.98) remained as the additive effect of preeclampsia to risk of ischaemic heart disease, corrected for cardiovascular risk factors. For stroke, an odds-ratio of 1.17 was calculated based on the difference of cardiovascular risk factors after a history of preeclampsia compared to a healthy pregnancy. Dividing the observed odds-