Page 104 - Pro-active Management of Women’s Health after Cardiometabolic Complicated Pregnancies

102 | Part 3 Lifestyle intervention
term we used “lowering lipids OR dyslipidaemia OR hypercholesterolemia” and “lowering blood pressure OR hypertension”, respectively. Non-human studies and non-English articles were excluded. However, neither search provided any usable studies (figure 3.2.2). Therefore, we used the Cochrane Library to select studies reporting on the effects on lipid profile and blood pressure after primary interventions205. We selected studies reporting on effects in women aged 30-60 years. Studies were categorised according to cardiovascular risk factor (table 3.2.4). Next, for each cardiovascular risk factor the median value of the reported effects was calculated. This resulted in a collection of median effects of lifestyle intervention on the cardiovascular risk factors as shown in the second column of table 3.2.1. For each risk factor, a 1st and 3rd quartile value was calculated.
In step 2b we calculated the difference in cardiovascular risk factors between women with a history of preeclampsia with or without lifestyle interventions. The same studies as found in step 1a were used. The reported values of women with a history of preeclampsia were considered to be without the effect of lifestyle interventions. To compile a new fictive dataset with values of women with a history of preeclampsia that would have had lifestyle interventions, the collection of median effects of lifestyle interventions (step 2a) was used to recalculate the values of the cardiovascular risk factors into new values, as if these women would have had lifestyle interventions after preeclampsia.
In step 2c we calculated the difference in cardiovascular risk factors between women with a history of preeclampsia with or without lifestyle interventions. For each cardiovascular risk factor the median value and interquartile range of the difference between the original and the fictive, recalculated values as provided in step 2b was calculated by subtraction. This resulted in a collection of median differences of the cardiovascular risk factors