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3.2 Effect of Lifestyle Interventions after Preeclampsia| 105
ratio of 1.81 with this calculated odds-ratio of 1.17, an odds-ratio of 1.55 (1.40- 1.71) remained as the additive effect of preeclampsia to risk of stroke, corrected for cardiovascular risk factors.
Estimated effect of lifestyle interventions on cardiovascular risk after preeclampsia
The included studies are listed in table 3.2.4 categorised by cardiovascular risk factor. Table 3.2.1 shows the median and interquartile range of the effects for each cardiovascular risk factor.
Based on these values we estimated the odds-ratios for cardiovascular disease after lifestyle interventions in former preeclamptic women to be between 0.87-0.96 (table 3.2.2).
DISCUSSION
Main findings
Our estimates showed that cardiovascular risk factors used in the prediction models did not fully explain the risk of cardiovascular disease after preeclampsia. A major part of the observed odds-ratios of cardiovascular disease after preeclampsia remained after adjustment for these cardiovascular risk factors.
According to our estimates, lifestyle interventions after preeclampsia will decrease the cardiovascular risk by 4-13%. This might be an underestimation, since we had to use studies that did not account for possible motivational effects of having had preeclampsia186 205 206. On the other hand, the duration of follow- up of the studies was well below the time-span of the prediction models. Thus, a possible rebound effect after cessation of the interventions would lower the