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Alveolar iodine tampon packing after impacted third molar surgery improves oral health-related quality of life975evaluated three types of drainage methods and concluded that the tube drain group showed better results than the rubber drain and gauze drain groups, due to a stronger drainage effect. Akota et al. [16]assessed the post-surgical effects of locally applied gauze drain impregnated with chlortetracycline ointment and concluded that the impregnated drain effectively reduced alveolar osteitis. However, they did not find any beneficial effects on postoperative pain, swelling, or trismus. Rakprasitkul et al. [48] compared primary closure with placement of a tube drain after surgery, and found that surgical drainage did not influence pain but had a significant positive effect on postoperative swelling and trismus, which is in agreement with the finding of Egbor et al. [15]. Benediktsdóttir et al. reported that the use of an ice pack to cool the masseteric region, starting immediately after surgery, resulted in significantly reduced swelling and trismus (p < 0.05) on postoperative days one, two, and seven [37]. However, Van der Westhuijzen et al. [49] and Zandi et al. [50] did not find any significant difference in postoperative sequelae with the application of an ice pack after third mandibular surgery in their studies. In our present study, immediately after the operation, patients in both groups were given an ice pack and instructed to apply it to the cheek on the side of intervention in 10-min intervals. Although both groups used ice packs, the two groups in our study exhibited significantly different degrees of swelling, based on the overall mean OHIP-14 sum scores measured on the first three days postoperatively. Notably, Benediktsdóttir et al.reported that level of impaction was correlated with postoperative pain [37]. In our present study, the Mann-Whitney U-test showed that no significant differences in impaction grade between the iodine tampon group and the Monoject® syringe group (U = 735.00, z = −1.91, p = 0.56). However, the iodine tampon group included more patients with a higher impaction grade compared to the Monoject® syringe group. Thus, with all other things being equal, the iodine tampon group was at a greater risk for postoperative pain. Considering that patients in the iodine tampon group perceived less postoperative sequelae, it is likely that the effect of an alveolar iodine tampon on OHRQoL would have been even greater than in our present results if both groups had been equal.