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Alveolar iodine tampon packing after impacted third molar surgery improves oral health-related quality of life915PI-NRS: iodine tampon versus Monoject® syringeTo assess the use of an iodine tampon compared with the Monoject® syringe in terms of the measured pain intensity score during the first postoperative week, we carried out two separate RMA and independent-samples t-tests, comparing the PI-NRS scores for both groups on each postoperative day. RMA analysis revealed a statistically significant effect of time in the iodine tampon group [F (6, 258) = 46.48, p < 0.001, ηp2 = 0.52] as well as in the Monoject®syringe group [F (6, 252) = 57.64, p < 0.001, ηp2 = 0.58]. A pairwise comparison of the PI-NRS score over seven postoperative days in the iodine tampon group revealed that all measurements declined over time and significantly differed from each other, except between postoperative days 1–2 (p = 0.065). Pairwise comparison of the mean PI-NRS score over seven postoperative days in theMonoject® syringe group showed that the mean scores declined over time, with significant differences between all days (p <0.05). We additionally carried out a repeated measures ANOVA between-subjects factor analysis to evaluate differences in the PI-NRSbetween the two conditions. The results revealed that the mean PI-NRS significantly differed between the iodine tampon group (3.33; SE, 0.27) and Monoject® syringe group (4.46; SE, 0.27) [F (1, 85) = 8.16, p < 0.01], and we found no interaction effect between time and condition on the PI-NRS [F (6, 510) = 1.26, p = 0.28].To determine the effect of the iodine tampon compared to use of the Monoject® syringe, we performed independent-samples t-test analysis on PI-NRS scores for the seven postoperative days. Table 5 shows the differences in mean PINRS scores between the iodine tampon and Monoject® syringe conditions on each postoperative day. The results showed that the mean PI-NRS scores in the iodine tampon group were significantly lower from post-operative day 1 up to and including postoperative day 4. The two groups did not significantly differ on the subsequent postoperative days.