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Chapter 460The aim of this study was to assess the efficacy of an iodine tampon in the extraction socket after mandibular third molar surgery regarding OHRQoL in the first postoperative week. We also assessed the effect of alveolar tampon packing on postoperative pain, AO, and pain medication and infection in the week following third molar surgery. Material and methodsStudy design and patient selectionThis article is reported according to the CONSORT (Consolidation Standards of Reporting Trials) statement for providing the quality of reports of randomized trials (http://www.consort-statement.org/).61 The study was designed as a prospective randomized crossover study in patients who were referred to the Department of Oral and Maxillofacial Surgery of Amstelland Hospital (Amstelveen, the Netherlands) for surgical removal of two impacted mandibular third molars. Only native Dutch speakers with bilateral horizontally impacted mandibular third molars, with a Gregory-Pell 3B grade impaction,35 who were planning to undergo bilateral mandibular third molar surgery were included in the study. Other inclusion criteria were age ≥18 years; American Society of Anesthesiology (ASA) 1, patients with no systemic diseases or medical conditions; no discernible active pathology associated with the third molars, and no acute pericoronitis; and the patient was free of periodontal disease.Exclusion criteria were smoking, allergy to ibuprofen, presence of systemic disease, history of recent and/or symptomatic peptic ulcer, anti-platelet or anticoagulant therapy, pregnancy or lactating, recent local infection prior to surgery (<15 days), previous radiation therapy to the maxillofacial region, local pathology (e.g., cysts or tumor) associated with the third molars, or lack of consent to the procedure or the study.Data collection occurred from January 1, 2016, to July 31, 2017. The study was performed with the understanding and written consent of each subject and according to the ethical principles described in the Declaration of Helsinki. The research protocol was reviewed and approved by the medical ethical committee