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Effect of periapical surgery on oral health-related quality of life1337the first postoperative week for pain scores and ASA group, surgical flaps, location of teeth, or operation time. Comparing the second molar region with the other locations, we found no significant differences during the week for the NRS pain scores, or even during the first 3 days (day 1, p=0.30; day 2, p=0.32; day 3, p=0.29). Figure 2 shows the pain scores versus the location of the operated teeth.Figure 2: Mean numeric rating scale (NRS) pain score per location during the 1st postoperative week. Error bars indicate SD.-202468Day 1 Day 2 Day 3 Day 4 Day 5 Day 6 Day 7Mean NRS scorePostoperative daysMean Pain scoreAnterior Maxilla Premolar Maxilla Molar MaxillaAnterior Mandible Premolar Mandible Molar MandibleAnalgesic intake Repeated measures were used to determine mean scores over time for pain from postoperative days 1 to 7. Repeated measures ANOVA was used to analyze mean analgesic intake each day during the first postoperative week (Table 3). We found a significant effect for the repeated measurements (F(6, 127) = 26.8, p < 0.001). Subsequent pairwise comparisons show that the mean analgesic use decreased significantly throughout the week. Only the mean scores from day 4 and 5, and day 6 and 7 did not differ significantly (p=1.00), whereas all of the mean scores on the other days differed significantly from each other (p<0.05). We found no significant interaction effect during the first postoperative week for mean analgesic intake and gender, ASA group, smokers, surgical flaps, operation time, or location of teeth. Figure 3 shows the mean number of analgesic intake for the location of the operated teeth. On the first postoperative day, 14.3% of patients reported not using any analgesics. This percentage increased to 30.8% on day 2 and 42.1% on day 3. On the seventh day, 23.3% of the patients used analgesics.