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                                    Effect of periapical surgery on oral health-related quality of life1297Statistical analysisData were analyzed using SPSS version 25 (SPSS Inc., Chicago, IL, USA). Significance was set at α=0.05. To obtain the overall mean OHIP-NL14 score, all 14 questions were averaged for each day, and this score was used to compare changes over time and between groups. Repeated measures ANOVA within subjects was performed to assess the change over time (day 1 - day 7). Additional analyses were conducted to determine the relationship between OHRQoL and the other study variables (age, gender, smoking, ASA classification, and tooth position) over time by means of univariate analysis of variance. Between-group comparisons were performed by means of independent t-tests. ResultsA total of 133 patients (54 [40.6%] males and 79 [59.4%] females) participated in this study, and all questionnaires were included in the study. The mean patient age was 50.8 years (SD 14.7) for the whole population, 50.7 years (SD 14.8) for the males, and 51 years (SD 14.7) for the females. Surgery was performed in 22 maxillary anterior teeth (16.5%), 29 maxillary premolars (21.8%), 37 maxillary molars (27.8%), 3 mandibular anterior teeth (2.3%), 5 mandibular premolars (3.8%), and 37 mandibular molars (27.8%). OHIP-14 scoresOf the 133 returned questionnaires, the mean overall OHIP-14 score was determined for postoperative day 1 to 7 (Table 1). Repeated measures ANOVA was used to analyze the mean overall OHIP-14 scores collected each day during the first postoperative week, indicating a significant effect for the repeated measurements (F(6, 792) = 72.8, p < 0.001). Subsequent pairwise comparisons indicated that the mean OHIP-14 scores decreased significantly throughout the week. Only the mean scores from day 5 and day 6 did not differ significantly (p=0.11), whereas all the mean scores on the other days differed significantly from each other (p<0.05). No significant differences in mean OHIP-14 scores were found for gender, ASA score, surgical flaps, or operation time. Smokers had a significantly higher OHIP-14 score on the first postoperative day than non-smokers. Patients who had a postoperative infection had a significantly higher OHIP-14 score on the fifth postoperative day. Younger patients had a 
                                
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