Page 34 - Assessing right ventricular function and the pulmonary circulation in pulmonary hypertension Onno Anthonius Spruijt

2
Threshold False probability % Positives
1 25 2 24 5 22 10 19 15 18 20 18 Threshold probability %
NB PH all
NB Model 1: PA/AAAX
Delta NB
Decrease in false positives (per 100 patients) without
false
0.6677299
0.6643394
0.6537396
0.6345029
0.6130031
0.5888158
NB PH all NB Model 2:
0.0000000
0.0002685
0.0020776
0.0087720
0.0030960
-0.0032895
Delta NB Decrease in false positives
(per 100 patients) without an increase in false negatives
0.0009304 9
0.6677299 0.6646079 0.6558172 0.6432749 0.6160991 0.5855263
an increase in negatives
0
1
4 8 2 -1
PA/AAAX + RV/LVAX
1 18 0.6677299 0.6686603
2 17 5 13 10 10 15 9 20 7 Threshold probability %
0.0021482
0.0083102
0.0219298
0.0371517
0.0592105
Delta NB Decrease in false positives
(per 100 patients) without an increase in false negatives
0.0011962 12
0.6643394
0.6537396
0.6345029
0.6130031
0.5888158
NB PH all NB Model 3:
0.6664877 0.6620499 0.6564328 0.6501548 0.6480263
11 16 20 21 24
PA/AAAX + RV/LV4CH
1 16 0.6677299 0.6689261
2 14 5 10 10 8 15 6 20 6
0.6643394 0.6537396 0.6345029 0.6130031 0.5888158
0.6672932 0.6641274 0.6593567 0.6571207 0.6513158
0.0029538 0.0103878 0.0248538 0.0441176 0.0625000
14 20 22 25 25
Table 6: Net benefits(NB) of model 1, 2 and 3. The net benefit (NB) is calculated as: NB = (true positives / n) – ((false positives / n) x (Pt / (1-Pt)). Subsequently, the decrease in false positives per 100 patients without an increase in false negatives is calculated as: (NBmodel – NBall) x 100(Pt / 1-Pt). Pt = Threshold probability [21, 22].