Page 99 - Physiological based CPAP for preterm infants at birth Tessa Martherus

Part I: Comparing CPAP Strategies
High-CPAP does not impede cardiovascular changes at birth in preterm sheep
During the first 30 min after birth, mean (p=0.002) and end-diastolic (p=0.016) PBF (median (Q1-Q3) over 30 min) were significantly lower in the LCPAP group compared to the HCPAP and dynamic HCPAP groups (Figures 2A, B and Table 2). There was no difference in CBF (p=0.166) or CBF variability (p=0.218) between the LCPAP, HCPAP and dynamic HCPAP groups over the 30 min period after birth (Figure 2C and Table 2). BAP (p=0.037) was lower in the LCPAP group compared to the HCPAP and dynamic HCPAP group (Figure 2D and Table 2). Heart rates were lower (p=0.028) in the LCPAP group compared to the dynamic HCPAP group but were not different to the HCPAP group (Figure 2E and Table 2).
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Figure 2. Cardiovascular outcomes. Median (Q1-Q3) of a) mean and b) end-diastolic pulmonary blood flow (PBF), c) cerebral blood flow (CBF), d) mean brachial artery pressure (BAP) and e) heart rate in lambs receiving LCPAP vs HCPAP vs dynamic HCPAP in the first 30 minutes after birth (t0=cord clamping). All parameters were compared over time using linear mixed-effect regression models. One (*) or two asterisks (**) indicate significant difference between the LCPAP vs (dynamic) HCPAP or LCPAP vs both HCPAP groups, respectively.
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