Page 98 - Physiological based CPAP for preterm infants at birth Tessa Martherus

Chapter 4
79/100*(X-0.21)))). The data included in the analysis were obtained either throughout the study duration, including during iPPV, or until reaching the ethical endpoint of intubation. Group p-values were used to compare means between groups. Post-hoc analyzes were performed using the False Discovery Rate. Data are presented as the median (Q1-Q3) of the group effect in the first 30 min after birth.
As rescue interventions were allowed, a comparison between groups did not reflect the effect of CPAP alone. To clarify the impact of iPPV and additional caffeine treatments on the results, the effect of successful interventions was explored using Wilcoxon Signed-Rank Test. Interventions were deemed successful if lambs continued spontaneously breathing on CPAP after iPPV or if breathing improved after the additional caffeine administration.
JVP was compared between CPAP levels using a Kruskal-Wallis Test. UTP and CPAP pressures were compared with a Wilcoxon Signed-Rank Test. The effect of a change in CPAP pressure was analyzed using Friedman's test as missing values were completed using the mean value of the group.
Results
Lambs allocated to the LCPAP (n=6), HCPAP (n=6), or dynamic HCPAP (n=7) groups showed no differences in baseline characteristics at birth (Table 1). In the dynamic HCPAP group, CPAP was reduced after a median (Q1-Q3) of 13.4 (8.4-20.3) min after birth, when PBF was 339 (288-423) mL/min and SaO2 was 91 (86-96) %, while supported by a FiO2 of 0.59 (0.29- 0.68).
Table 1. Baseline characteristics
LCPAP (n=6)
HCPAP Dynamic HCPAP P-value (n=6) (n=7)
Birth weight (kg) Twins (n, %) Gender (male n, %) Meconium (n, %) pH at birth
PaCO2 at birth (mmHg)
PaO2 at birth (mmHg)
SaO2 at birth (%)
3.2 (2.7-3.8) 6/6 (100%)
2/6 (33%)
2/6 (33%)
7.31 (7.19-7.35) 50.4 (43.6-69.3)
11.0 (5.5-16.0) 20.7 (4.4-31.4)
3.5 (3.0-3.7) 4/5 (80%)*
3/6 (50%)
2/5 (40%)*
7.31 (7.27-7.34) 55.3 (51.6-58.1)
14.7 (11.1-18.2) 27.2 (20.4-42.6)
3.4 (3.0-3.8) 7/7 (100%)
2/7 (29%)
2/7 (29%)
7.26 (7.24-7.27) 49.7 (47.4-55.9)
9.7 (6.5-17.3) 8.7 (6.6-43.4)
0.908 0.278 0.844 1.000 0.124 0.467
0.594 0.310
Data presented as n (%) or median (Q1-Q3). * N=1 missing value.
94