Page 100 - Physiological based CPAP for preterm infants at birth Tessa Martherus

Chapter 4
Breathing rates were lower in the LCPAP group (p=0.009) compared to the HCPAP and dynamic HCPAP groups, whereas inter-breath variability was not different between groups (p=0.412, Figure 3A and Table 2). The need for rescue interventions was statistically similar (p=0.082) between groups, although only 1/6 (17%) HCPAP treated lambs received rescue treatments, whereas 5/6 (83%) LCPAP, and 5/7 (71%) dynamic HCPAP lambs received rescue interventions (Figure 3B and Table 2). Nevertheless, more LCPAP lambs (3/6 (50%)) reached the point at which intubation was required, compared with (0/6 (0%)) HCPAP and (0/7 (0%)) dynamic HCPAP lambs (p=0.041). During post-mortem examination, 1/6 (17%), 0/6 (0%), and 0/7 (0%) lambs of the LCPAP, HCPAP, and dynamic HCPAP group, respectively, had developed a pneumothorax (p=0.632).
Figure 3. Breathing and support. Median (Q1-Q3) a) breathing rate, b) rescue interventions, c) fraction of inspired oxygen (FiO2) and d) alveolar to arterial differences in PO2 (AaDO2) in lambs receiving LCPAP vs HCPAP vs dynamic HCPAP in the first 30 minutes after birth (time 0=cord clamping). All parameters were compared over time using linear mixed-effect regression models. One (*) or two asterisks (**) indicate significant difference between the LCPAP vs (dynamic) HCPAP or LCPAP vs both HCPAP groups, respectively. Dotted vertical lines (C) indicates the point of CPAP change in the dynamic HCPAP group.
96