Page 43 - Migraine, the heart and the brain

Structural Brain Changes in Migraine
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Table 2. Prevalence and Progression of Infarcts and Deep White Matter and Infratentorial Hyperintensities
Deep white matter hyperintensities Men, No. (%)
P ValueA .67
Without Aura (n = 89) 25 (28)
With Aura (n = 114) 33 (29)
P ValueA >.99
Lesion volume, median (IQR), mL Baseline 9-y Follow-up
Difference
Lesion progression, No. (%)b
0.04 (0.00-0.20) 0.14 (0.01-0.67) 0.08 (0.01-0.43) 21 (81)
0.02 (0.00-0.07) 0.06 (0.08-0.34) 0.04 (0.00-0.29) 40 (69)
.18 .36 .31 .30 .78 .64
0.01 (0.00-0.08) 0.05 (0.00-0.15) 0.04 (0.00-0.10) 15 (60)
0.02 (0.00-0.09) 0.11 (0.01-0.42) 0.08 (0.01-0.31) 25 (76)
.76 .47 .47 .26 >.99 .50
High progression, No. (%)c New lesions Median (IQR)
6 (23) 3(1-11)
12 (21) 3 (0-8)
5(20) 3 (0-5)
7(21)
4 (0-10)
≥10, No. (%)
Mean volume, median (IQR)
8(31)
0.03 (0.01-0.05) 57 (69)d
0.00 (0.00-0.04)
12 (21)
0.02 (0.01-0.04) 145 (71)
0.02 (0.00-0.09)
.41 .23 .67 .009
4(16)
0.02 (0.01-0.07) 64 (72)
0.03 (0.00-0.12)
8 (24)
0.02 (0.01-0.04) 81 (71)
0.01 (0.00-0.06)
.53 .65 >.99 .08
Women, No. (%)
Lesion volume, median (IQR), mL Baseline
9-y Follow-up
Difference
Lesion progression, No. (%)b High progression, No. (%)c New lesions
Median (IQR)
>10, No. (%)
Mean volume, median (IQR)
0.04 (0.00-0.19) 0.02 (0.00-0.14) 33 (60)
5(9)
0.09 (0.02-0.34) 0.05 (0.01-0.27) 112 (77)
33 (23)
.04 .04 .02 .03
0.16 (0.02-0.43) 0.11 (0.01-0.36) 53 (83)
19 (30)
0.05 (0.01-0.28) 0.04 (0.00-0.15) 59 (73)
14(17)
.03 .04 .17 .11
Controls (n = 83) 26 (31)
Migraine (n = 203) 58 (29)
Migraine Headache
1 (0-6)
5(9)
0.02 (0.01-0.04)
3 (0-11)
43 (30)
0.02 (0.01-0.03)
.04 .003 .97
1 (0-9)
25 (39)
0.02 (0.01-0.03)
5 (0-16)
18 (22)
0.02 (0.01-0.04)
.10 .03 .59