Page 41 - Migraine, the heart and the brain

Structural Brain Changes in Migraine
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eTable 2. Migraine characteristics in relation to MRI outcome measures as compared to controls (Females only)
Duration of migraine
< 29 yrs ≥ 29 yrs
1.8 [0.6-4.9] 1.2 [0.4-3.3]
P=.3 P=.8 P*=.2
2.9 [1.3-6.7] 1.5 [0.7-3.2]
P=.06 3.3 [1.0-9.9] 1.6 [0.5-5.0]
P=.08 11.2 [1.4-90.1] P=.1 4.9 [0.6-41.8]
low 25% high 25%
0.5 [0.1-1.6] 0.7 [0.3-2.0]
0.9 [0.3-2.4] 0.3 [0.1-1.0]
P=.04 0.7 [0.2-2.2] 0.6 [0.2-1.8]
P=.5 2.1 [0.7-6.4] P=.2 0.5 [0.1-1.9]
median (IQR) of those with lesions median (IQR) of those without
23 (11-39) 20 (0-34)
22 (7-34) 15 (0-36)
P*=.1 23 (16-38) 20 (0-34)
P*=.1 24 (15-37) P*=.2 20 (0-34)
Migraine subtype
without aura with aura
1.8 [0.7-5.1] 1.2 [0.4-3.2]
P=.3
2.9 [1.2-6.7] 1.7 [0.8-3.5]
P=.2 3.3 [1.1-9.9] 1.6 [0.5-5.0]
P=.1 11.5 [1.4-92.9] P=.1 5.0 [0.6-41.7]
Number of headache attacks
<median (lifetime) ≥median (lifetime)
1.7 [0.6-4.7] 1.3 [0.5-3.5]
P=.5 P*=.9
1.9 [0.9-4.2] 2.2 [1.0-4.9]
P=.9 2.8 [0.9-8.7] 1.9 [0.6-5.8]
P=.4 8.9 [1.1-73.3] P=.5 6.7 [0.8-55.0]
median (IQR) of those with lesions median (IQR) of those without
271 (107-646) 264 (168-480)
274 (123-575) 252 (174-353)
P*=.4 263 (105-581) 274 (173-496)
P*=.6 284 (100-923) P*=.9 264 (159-496)
<median (FU only) ≥median (FU only)
1.9 [0.7-5.5] 1.2 [0.4-3.3]
P=.3 P*=.7
2.1 [0.9-4.7] 2.2 [1.0-4.5]
P=.8 3.2 [1.0-9.9] 1.9 [0.6-5.6]
P=.2 12.3 [1.5-101.5] P=.1 5.3 [0.6-43.8]
Mean attacks per month, median (IQR) of those with lesions
of those without lesions
0.7 (0.4-1.9) 0.9 (0.5-1.5)
1.0 (0.5-1.6) 0.6 (0.4-1.0)
P*=.09
0.8 (0.4-1.8) 0.9 (0.5-1.5)
P*=.8 P*=.6 0.8 (0.5-2.2)
Headache activity status
0.9 (0.4-1.5)
P=.03 10.2 [1.1-93.1] P=.6
inactive at baseline active at baseline
3.4 [1.1-10.7] 1.1 [0.4-2.8]
P=.03 P=.5
3.1 [1.0-9.5] 1.9 [0.9-3.8]
P=.4 5.3 [1.5-18.1] 1.7 [0.6-5.1]
7.0 [0.9-55.6]
P=.7 5.7 [0.7-47.4] P=.2
inactive during 9 year FU active during 9 year FU
1.8 [0.6-5.0] 1.2 [0.4-3.4]
2.9 [1.0-5.4] 1.9 [0.9-4.1]
P=.9 2.6 [0.8-8.1] 2.1 [0.7-6.3]
10.6 [1.3-87.0]
High DWMH load at FU
Progression of DWMH load
High progression of DWMH load
Progression of IH