Page 125 - Functional impairment and cues for rehabilitation of head and neck cancer patients -

Table 3 Trismus outcomes at t0, t1 and t2. P values shown for Friedman testa, Cochran’s Q testb, Wilcoxon signed rank testc or McNemar testd. ↑ indicating more problems and ↓ indicating less problems.
Functional outcomes after (C)RT for OPC
Total
P value t0, t1, t2
P value t0 to t1
P value t1 to t2
P value t0 to t2
t0
n = 108
t1
n = 99
t2
n = 71
Observer-rated outcomes
Mouth opening in mm
48 (18-65)
98 (94) 6 (6)
4
87 (97)
3 (3) 18
45 (16-63)
68 (77) 20 (23) 11
67 (82)
15 (18) 17
43 (10-64)
55 (80) 14 (20) 2
56 (89)
7 (11) 8
<.001c ↑ <.001d ↑
.022d ↑
.497c <.001c ↑ 1.000d .039d ↑
.065d .453d
Median (range)
Trismus
Perceived trismus
No
Yes Unknown
No
Yes Unknown
<.001a .006b
Patient-rated outcomes
.082b
NB: Not all percentages sum up exactly to 100% due to rounding.
Abbreviations: FOIS = functional oral intake scale, NGT = nasogastric tube, PRG = percutaneous radiological
gastrostomy, t0 = pretreatment, t1 = six months after treatment, t2 = twelve months after treatment
Table 4 Speech and voice outcomes at t0, t1 and t2. P values shown for Friedman testa, Cochran’s Q testb, Wilcoxon signed rank testc or McNemar testd. ↑ indicating more problems and ↓ indicating less problems.
5
Total
P value t0, t1, t2
P value t0 to t1
P value t1 to t2
P value t0 to t2
t0
n = 108
t1
n = 99
t2
n = 71
Observer-rated outcomes
Vowel Space Area (%)
85 (51-129)
59 (63) 35 (37) 14
0 (0-42) 0 (0-39) 0 (0-83) 65 (83) 13 (17) 30
2.3 (0.2-7.7) 4.5 (3.3-5.3)
79 (49-107)
37 (49) 39 (51) 23
2 (0-32) 0 (0-34) 3 (0-61) 39 (66) 20 (34) 40
2.6 (0.6-6.1) 4.5 (3.4-5.5)
.015c↑ .210d
.005c ↑ .476c .001c ↑ .006d ↑
2.7 (0.1-6.1)
4.5 (3.6-5.5) .905c
.002c↑ .019d↑
.580c .281c .640c .500d
.698c .473c
Median (range)
Vowel Space Area < 80%
No
Yes Unknown
77 (51-112)
24 (42) 33 (58) 14
0 (0-31) 0 (0-15) 0 (0-40) 36 (88) 5 (12) 30
.137c .344d
.045c ↓ .236c .073c .453d
.626c .723c
.014a .050b
Patient-rated outcomes
SHI Median (range)
Speech domain (0–56) Psychosocial domain (0–56) Total score (0–120)
SHI ≥ 6
No
Yes Unknown
.076a .326a .190a .074b
Secondary outcomes
Articulation rate (syllables/s) Median (range) AVQI Median (range)
.302c
.739a .901a
NB: Not all percentages sum up exactly to 100% due to rounding.
Abbreviations: AVQI = acoustic voice quality index, FOIS = functional oral intake scale, NGT = nasogastric
= percutaneous radiological gastrostomy, SHI = speech handicap index, t0 = pretreatment, t1 = six months after treatment, t2 = twelve months after treatment
tube, PRG
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