Page 35 - Bladder Dysfunction in the Context of the Bladder-Brain Connection - Ilse Groenendijk.pdf

A systematic review and meta-analysis of the central innervation of the lower urinary tract 33
2
Table 2. Study characteristics of fMRI studies. (continued) Main study details
Task
paradigm
Scan details and analysis
Group MNI
Study N
Healthy volunteers?
Age M/F
Main task
Concomi- tant tasks
Control task
Design: Block or event related
Main task repetition
Bladder status
Bladder filling
Tesla
-TR -TE -FoV -ST
Software
Smooth Gaussian
analyses model
or TAL
Threshold P value
Kuhtz- 22 Buschbeck, J.P.
et al (2005)
Healthy volunteers
24.5 0/22
PFMC
Initiate micturition, but not void
Rest
Block
5
Full (±300cc)
Natural
1.5T
-
- 50 - 220 - 3
SPM2
7 mm
Random effects
MNI
Corrected p= variable
Zhang, H. et al 12
(2005) volunteers
23.8 12/0
PFMC
None
PFMC with empty bladder
Block
8
Full vs empty
Natural
3T
- 2900 - 30
- 230 -5
SPM99
8 mm
Conjunction group analysis
TAL
Corrected
P = variable
MICTURITION
Khavari, R. et al 16a
(2017) sclerosis
46.8 0/16
Initiated micturition
None
Healthy controls
Event related
4
Full
Catheter
3T
- 3000 - 35
- 240 -4
AFNI
5 mm
-
MNI
P = 0.05
Michels, L. et al 14b
(2015) volunteers
26.4 14/0
Micturition
None
Rest
Event related
10
Full
Natural
3T
- 3000 - 35
- 220 -3
SPM5
8 mm
Random effects
MNI
FDR
P = 0.001
Shy, M. et al 10
(2014) volunteers
32.4 0/10
Micturition
None
Rest
Event related
4
Full
Catheter
3T
- 3000 -
-
-4
AFNI
-
-
MNI
Uncorrected P = 0.00027
Krhut, J. et al 6c
(2012) volunteers
49.6 0/6
Micturition
None
None
Event related
3
Full
Catheter
3T
- 3000 - 30
-
-3
SPM5
8 mm
-
MNI
Uncorrected P = 0.02
Kuhtz- 33 Buschbeck, J.P
et al (2009)
Healthy volunteers
26.4 16/17
Initiated micturition, but not void
None
Different bladder volumes
Block
5
Full
Natural
1.5T
-
- 50 - 220 - 3
SPM2
Random effects
MNI
FWE
P = variable
Healthy
Multiple
Healthy
Healthy
Healthy
Abbreviations: TR: Repetition time, TE: time of echo, FoV: Field of View, St: Slice thickness, TAL: talairach, PFMC: Pelvic floor muscle contraction. a Of 16 patients, 7 performed successful micturition but data was not reported separately.
b Originally 22 patients were included but only 14 performed successful micturition and data was reported separately
c Originally 12 patients were included but only 6 performed successful micturition and data was reported separately