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Post-traumatic stress in 22q11.2DS1977available clinical reports. As a consequence, PTSD prevalence may still have been underestimated.6 On the other hand, bias towards patients with 22q11.2DS with more severe mental health problems is possible, given that all patients were referred to a 22q11.2DS specialty clinic. Prospective studies are needed to replicate our findings, to further explore the risk of trauma, and to assess the effectiveness of trauma-focused treatments and resilience in 22q11.2DS.ConclusionsIn conclusion, PTSD and traumatic events appear to be more prevalent than previously assumed in adults with 22q11.2DS. Clinicians and other caregivers should thus be alert to PTSD in 22q11.2DS in order to minimize psychiatric burden with reduced quality of life. Systematic studies in individuals with 22q11.2DS are needed to improve diagnosis, using strategies adjusted to their strengths and weaknesses and including attention to seemingly unimportant life events that may be traumatic, and evaluate the efficacy of treatments in this population.Declaration of interestDeclaration of Interest: None.Funding This work was supported financially by Stichting Wetenschappelijk Onderzoek, ‘s Heeren Loo (#2210100).Data-availabilityThe data that support the findings of this study are available from the corresponding author, EB, upon reasonable request.