Page 197 - Characterization of genetic neurodevelopmental disorders at adult age, with a focus on 22q11.2 deletion syndrome - Emma Boersma

Post-traumatic stress in 22q11.2DS
reported in only one patient. An additional 17 patients (15.2%) experienced
other potential traumatic events including bullying (n=13, 11.6%), multiple
hospitalizations/surgeries (n=4, 3.6%) and out-of-home placement (n=4,
3.6%). Neither sex nor FSIQ were predictors of a PTSD diagnosis (p=0.58
and p=0.53 respectively).
Table 1. Trauma in 112 adults with 22q11.2 deletion syndrome
History of trauma N % 95% CI, %
Clinical PTSD diagnosis Traumatic events a,b
Sexual violence
Serious injury
Actual or threatened death
Other potential traumatic events c Multiple (≥ 2) traumatic events
Treatment for trauma-related conditions Treatment for any traumatic event
Eye Movement Desensitization Reprocessing
Cognitive behavioural therapy
Other
23
12
11
4
17 d 14 9 8.0 20.5
10.7
9.8
3.6
15.2 12.5 N % 17.9
17.0
1.8
1.8
3.0-13.0
13.0-28.0
5.0-16.4
4.3-15.3
0.2-7.1
8.6-21.8
6.4-18.6
95% CI, %
20
19
2
2
10.8-25.0
10.0-24.0
0-4.3
0-4.3
a
In one patient with PTSD, traumatic events were not specified.
b Meeting DSM-5 criteria for a traumatic event.
c Events not meeting DSM-5 criteria for a traumatic event.
d Irrespective whether DSM-5 criteria were met.
N=number, 95% CI=95% confidence interval, PTSD=post-traumatic stress disorder.
Treatment for trauma was reported in 20 patients (17.9%) and included eye
movement desensitization reprocessing (EMDR; n=19, 17.0%) therapy and
cognitive behavioural therapy (CBT; n=2, 1.8%); one patient received both
therapies. Of the 9 patients with PTSD, 8 were treated with EMDR therapy,
including one 1 with additional CBT. In those with PTSD, the treatment
response was noted to be effective in four, and minimal to absent in another
three patients. For one patient with PTSD the response to treatment was
not reported. Another patient with PTSD did not receive therapy; this was
considered not feasible due to significant neurocognitive decline.
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