Page 197 - Demo

Post-traumatic stress in 22q11.2DS1957reported in only one patient. An additional 17 patients (15.2%) experienced other potential traumatic events including bullying (n=13, 11.6%), multiple hospitalizations/surgeries (n=4, 3.6%) and out-of-home placement (n=4, 3.6%). Neither sex nor FSIQ were predictors of a PTSD diagnosis (p=0.58 and p=0.53 respectively).Table 1. Trauma in 112 adults with 22q11.2 deletion syndrome History of trauma N % 95% CI, %Clinical PTSD diagnosis 9 8.0 3.0-13.0 Traumatic events a,b Sexual violence Serious injury Actual or threatened death231211420.510.79.83.613.0-28.05.0-16.44.3-15.30.2-7.1Other potential traumatic events c 17 15.2 8.6-21.8Multiple (≥ 2) traumatic events d 14 12.5 6.4-18.6Treatment for trauma-related conditions N % 95% CI, %Treatment for any traumatic event Eye Movement Desensitization Reprocessing Cognitive behavioural therapy Other20192217.917.01.81.810.8-25.010.0-24.00-4.30-4.3a In one patient with PTSD, traumatic events were not specified.b Meeting DSM-5 criteria for a traumatic event.c Events not meeting DSM-5 criteria for a traumatic event.d Irrespective whether DSM-5 criteria were met.N=number, 95% CI=95% confidence interval, PTSD=post-traumatic stress disorder.Treatment for trauma was reported in 20 patients (17.9%) and included eye movement desensitization reprocessing (EMDR; n=19, 17.0%) therapy and cognitive behavioural therapy (CBT; n=2, 1.8%); one patient received both therapies. Of the 9 patients with PTSD, 8 were treated with EMDR therapy, including one 1 with additional CBT. In those with PTSD, the treatment response was noted to be effective in four, and minimal to absent in another three patients. For one patient with PTSD the response to treatment was not reported. Another patient with PTSD did not receive therapy; this was considered not feasible due to significant neurocognitive decline.