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Parkinson’s disease in 22q11.2DS1213Predictors to Parkinson’s diseaseBinary logistic regression analysis showed that age, but not sex, was significantly related to PD in adults with 22q11.2DS (Table 4). Table 4. Possible predictors of Parkinson’s disease in 856 adults with 22q11.2 deletion syndromeWald P OR 95% CIParkinson’s disease aAge (y) 27.57 <0.001 1.11 1.07 – 1.16Male sex 0.99 0.32 1.73 0.59 – 5.06Parkinson’s disease, including suspected cases bAge (y) 49.67 <0.001 1.12 1.08 – 1.15Male sex 0.18 0.672 1.19 0.53 – 2.67Table 2. Binary logistic regression analysis of possible predictors of Parkinson’s disease in adults with 22q11.2DS. Both models were significant: ap<0.001, Nagelkerke=0.237, bp<0.001, Nagelkerke=0.279. Y=years, OR= odds ratio, CI= confidence interval.Discussion The results of this study confirm that the prevalence of PD is higher in 22q11.2DS compared to the general population,8 1.8% vs 0.3%, and indicate that PD is related to age, but not sex, with a sharp increase in prevalence to more than 10% in those aged 50 years and older. Parkinson’s disease in adults with 22q11.2DSThe increase in PD prevalence is comparable to the sharp increase reported in the general population,8 although with an earlier onset in 22q11.2DS. This study was an extension of a previous single-center study that reported a prevalence of PD of 5.9% in 68 adults aged 35 to 64 years, based on a PD diagnosis according to the UK Parkinson’s Disease Society Brain Bank criteria.2 In that study, adults aged 18-34 years were not included in the reported PD prevalence, however if they were, PD prevalence of the total study sample (n=158)2 would be 2.5% (95% CI: 0.01-4.98), comparable to the findings of the current study. In contrast to studies in the general population,8, 9 and previous findings in 22q11.2DS,4 there were no differences in the prevalence of PD or age at motor onset, between males and females. In the general population there