Page 123 - Characterization of genetic neurodevelopmental disorders at adult age, with a focus on 22q11.2 deletion syndrome - Emma Boersma

Parkinson’s disease in 22q11.2DS
Predictors to Parkinson’s disease
Binary logistic regression analysis showed that age, but not sex, was
significantly related to PD in adults with 22q11.2DS (Table 4).
Table 4. Possible predictors of Parkinson’s disease in 856 adults with 22q11.2 deletion syndrome
Wald 95% CI
P OR Parkinson’s disease a
Age (y) 27.57 <0.001 1.11 1.07 – 1.16
Male sex 0.99 0.32 1.73 0.59 – 5.06
Parkinson’s disease, including suspected cases b
Age (y) 49.67 <0.001 1.12 1.08 – 1.15
Male sex 0.18 0.672 1.19 0.53 – 2.67
Table 2. Binary logistic regression analysis of possible predictors of Parkinson’s disease in
adults with 22q11.2DS. Both models were significant:
ap<0.001, Nagelkerke=0.237, bp<0.001,
Nagelkerke=0.279. Y=years, OR= odds ratio, CI= confidence interval.
Discussion
3
The results of this study confirm that the prevalence of PD is higher in
22q11.2DS compared to the general population,8 1.8% vs 0.3%, and indicate
that PD is related to age, but not sex, with a sharp increase in prevalence to
more than 10% in those aged 50 years and older.
Parkinson’s disease in adults with 22q11.2DS
The increase in PD prevalence is comparable to the sharp increase reported
in the general population,8 although with an earlier onset in 22q11.2DS.
This study was an extension of a previous single-center study that reported
a prevalence of PD of 5.9% in 68 adults aged 35 to 64 years, based on a
PD diagnosis according to the UK Parkinson’s Disease Society Brain Bank
criteria.2 In that study, adults aged 18-34 years were not included in the
reported PD prevalence, however if they were, PD prevalence of the total
study sample (n=158)2 would be 2.5% (95% CI: 0.01-4.98), comparable to
the findings of the current study.
In contrast to studies in the general population,8, 9 and previous findings in
22q11.2DS,4 there were no differences in the prevalence of PD or age at
motor onset, between males and females. In the general population there
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