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Chapter 3120Table 3. Clinical features of 14 adults with 22q11.2 deletion syndrome and suspected Parkinson’s diseaseCase Sex Age, y PD diagnosis Bradykinesia Rigidity Rest tremor Progression Antiparkinson use Antipsychotic use Comorbid conditions, remarks1 F 48 √ a NR NR NR NR - - Korsakoff syndrome2 F 57 √ a √ NR NR NR √ √ CD, wheelchair user3 F 63 √ a √ - - √ √ b √4 c M 20 - √ - √ NR - -5 F 46 - - √ √ √ - √6 M 46 - √ √ - √ - √7 M 48 - √ NR √ NR - √ CD, oral tardive dyskinesia8 F 50 - √ - - √ √ √9 M 55 - √ √ √ √ √ b √ CD 10 F 55 d - √ √ √ √ √ √ CD, Wheelchair user11 F 56 - √ √ - √ - √12 M 66 - √ √ - √ √ b √ CD, myoclonus, antecollis13 F 62 d - NR NR NR NR NR -14 F 69 - √ - √ √ - - CD, wheelchair usera All 3 had a clinical PD diagnosis: case 2 by a neurologist, and case 3 by a movement disorder specialist.b Three patients were known to have a good response on antiparkinsonian medication.c The only patient with dopaminergic imaging results available showed typical reduced presynaptic dopaminergic signaling.d Age at death.√ = yes, - = no, y = year, NR = not reported/unknown, PD = Parkinson’s disease, CD = cognitive decline.