Page 120 - Characterization of genetic neurodevelopmental disorders at adult age, with a focus on 22q11.2 deletion syndrome - Emma Boersma

118
Table 1. Prevalence of Parkinson’s disease in 22q11.2 deletion syndrome by sex and age
Total study sample Male Female
Established PD n
PD
n
PD
%
PD
95% CI n % PD
N
PD
%
PD
95% CI n % PD
n
PD
%
PD
95% CI
0
1
1
0
9
3
1
51.5
51.5
41.0
47.1
42.7
32.2
40.0
Including
suspected PD n
PD
n
PD
%
0.0 – 0.0
0.0 – 0.9
0.0 – 1.5
0.0 – 0.0
4.7 – 19.4
0.0 – 20.1
0.0 – 55.1
PD
95% CI n % PD
N
0.0
0.0
1.3
0.0
12.5
20.0
50.0
0
1
0
0
5
1
0
0.0
0.6
0.0
0.0
11.6
4.8
0.0
0.0 – 0.0
0.0 – 1.8
0.0 – 0.0
0.0 – 0.0
2.1 – 21.2
0.0 – 13.9
0.0 – 0.0
PD
%
PD
95% CI n % PD
n
PD
%
PD
95% CI
Age group, y
<20
20 – 29
30 – 39
40 – 49
50 – 59
60 – 69
70+
97
332
195
121
75
31
5
0.0
0.3
0.5
0.0
12.0
9.7
20.0
50
171
80
57
32
10
2
0
0
1
0
4
2
1
0.0 – 0.0
0.0 – 0.0
0.0 – 3.7
0.0 – 0.0
1.0 – 24.0
0.0 – 44.8
0.0 – 100
47
161
115
64
43
21
3
48.5
48.5
59.0
52.9
57.3
67.7
60.0
Overall, y 856 15 1.8 0.9 – 2.6 402 47.0 8 2.0 0.6 – 3.4 454 53.0 7 1.5 0.4 – 2.7
50+, y 111 13 11.7 5.7 – 17.7 44 39.6 7 15.9 5.1 – 26.7 67 60.3 6 9.0 2.1 – 15.8
Age group, y
<20
20 – 29
30 – 39
40 – 49
50 – 59
60 – 69
70+
97
332
195
121
75
31
5
0.0
0.6
0.5
3.3
18.7
22.6
20.0
0.0 – 0.0
0.0 – 1.4
0.0 – 1.5
0.1 – 6.5
9.9 – 27.5
7.9 – 37.3
0.0 – 55.1
0
1
1
2
5
3
1
0.0 – 0.0
0.0 – 1.7
0.0 – 3.7
0.0 – 8.3
3.0 – 28.2
1.6 – 58.4
0.0 – 100
48.5
48.5
59.0
52.9
57.3
67.7
60.0
Overall, y 856 29 3.4 2.2 – 4.6 402 47.0 13 3.2 1.5 – 5.0 454 53.0 16 3.5 1.8 – 5.2
50+ 111 22 19.8 12.4 – 27.2 44 39.6 9 20.5 8.5 – 32.4 67 60.3 13 19.4 9.9 – 28.9
y
=
years, n
=
number, PD
=
Parkinson’s disease, 95% CI
=
95% confidence interval.
0
2
1
4
14
7
1
50
171
80
57
32
10
2
51.5
51.5
41.0
47.1
42.7
32.2
40.0
0.0
0.6
1.3
3.5
15.6
30.0
50.0
47
161
115
64
43
21
3
0
1
0
2
9
4
0
0.0
2.1
0.0
3.1
20.9
19.0
0.0
0.0 – 0.0
0.0 – 1.8
0.0 – 0.0
0.0 – 7.4
8.9 – 33.1
2.3 – 35.8
0.0 – 0.0
Chapter 3