Page 156 - Coronary hemodynamics in acute myocardial infarction - Matthijs Bax

Chapter 9
velocity at baseline (BMR), and during hyperaemia (HMR), in the culprit and in the absence of significant epicardial disease in the non-culprit vessel. The delta microvascular resistance from resting to hyperaemic conditions (dMR) was determined by calculating the absolute difference between BMR and HMR.
Statistical analysis
Normality of the data was tested using the Shapiro–Wilk test, and homogeneity of variance was tested with Levene’s test. All continuous variables are presented as mean ± standard deviation or median (25th to 75th percentile) according to their normal or non-normal distribution. Categorical variables are presented as counts and percentages. Analyses of linear trends across CFC categories were performed with polynomial contrasts.
Improvement of CFC in the culprit and non-culprit vessel between baseline, one week and six months was assessed by a Kruskal–Wallis test with pairwise post hoc correction for multiple comparisons. A p-value < 0.05 was considered statistically significant.
The STATA version 13.1 (StataCorp, College Station, Texas, USA) software package was used to perform statistical analyses.
Results
In total, 98 patients were included in the study at baseline, for which the baseline characteristics are listed in Table 1. The mean age of this cohort was 56±12 years, and 81% were male. Repeat coronary angiography and intracoronary measurements at one-week and six-month follow-up have been performed in a total of 64 and 65 patients respectively.
Relationship of CFC with procedural characteristics
Across CFC groups determined in the culprit vessel directly after primary PCI, linear contrast analysis revealed a significant trend in infarct size as determined by peak troponin T (p = 0.004), time to reperfusion (p = 0.038), the incidence of respectively final TIMI 3 flow (p = 0.019) and systolic retrograde flow (p = 0.043) (Supplemental file 1 online). For CFC determined for the non-culprit vessel linear contrast analysis revealed a significant trend in C-reactive protein
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