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Chapter 6108Conclusions Interappointment emergencies can occur any time during the course of a root canal treatment, not only days but also weeks following intervention. However, most seem to occur within the first two weeks following intervention. Omitting the use of intracanal medicament in multiple-visit root canal treatment did not significantly increase the incidence of interappointment emergencies. The present work may encourage to reconsider using intracanal medication in multiple-visit root canal treatment. Conflicts of interestNo potential conflict of interest relevant to this article was reported.FundingNo grants or other sources of support are received in relation to this study.Authors’ contributions Conceptualization: Baaij A, Özok AR; Data curation: Baaij A, Jansen M; Formal analysis: Baaij A, Jansen M; Funding acquisition: n/a; Investigation: Baaij A, Jansen M, Özok AR; Methodology: Baaij A, Visscher CM, Jansen M, Özok AR; Project administration: Özok AR; Resources: Özok AR; Software: n/a; Supervision: Baaij A, Visscher CM, Özok AR; Validation: Baaij A; Visualization: Baaij A; Writing - original draft: Baaij A; Writing - review & editing: Baaij A, Visscher CM, Jansen M, Özok AR. Acknowledgments We would like to thank Ms H.H. Alferink for extracting the patient records from the axiUm Dental Software, Ms L.N. Ali for collecting data for this study, and Prof. M. Væth for his great help regarding the statistics and visualization of this study.Annemarie Baaij.indd 108 28-06-2023 12:26