Page 136 - Helicobacter pylori and Gastric Cancer: From Tumor microenvironment to Immunotherapy

Chapter 6
Chapter 6
The apparent absence of babA2 and babB alleles in GC patients raise, however, hopes that larger studies may establish the usefulness of these alleles in guiding patient management.
Table 3: Combination of babA2, babB and iceA1 genotypes and clinical outcome
(Presence of a gene= positive, absence of a gene= negative, Pv: p-value)
babA2 babB iceA1
GC NUD PUD
(n=9) (n=81) (n=19)
Total
(n=109)
p- value
Positive
Positive
Positive
0
19
6
25
0.113
Positive
Positive
Negative
0
15
3
18
0.121
Positive
Negative
Positive
0
12
2
14
0.136
Positive
Negative
Negative
0
9
4
13
0.196
Negative
Positive
Positive
3
7
1
11
0.216
Negative
Positive
Negative
0
11
2
13
0.157
Negative
Negative
Positive
6
3
1
10
0.001
Negative
Negative
Negative
0
5
0
5
0.253
Discussion
Various studies have observed substantial differences in incidence and/or severity of gastroduodenal pathologies related to H. pylori which may vary according to geographical regions [26]. Although many factors may contribute to these differences, an obvious contributing factor is the different distribution of pathogenic markers in circulating strains [18]. The clinical relevance of the putative virulence- associated genes of H. pylori and geographical region remains controversial. Other factors that influence the risks for atrophy and cancer in the presence of infection may be related to the time when infection occurred, to other environmental factors and to the host genetic variation [27]. In particular single nucleotide polymorphisms in genes that influence bacterial handling via pattern recognition receptors appear to be involved, further strengthening the link between host risk factors, H. pylori
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