Page 138 - Helicobacter pylori and Gastric Cancer: From Tumor microenvironment to Immunotherapy

likely dependent on the geographic origin of the H. pylori strains. Survey of previous studies on Portuguese, Thai and India populations showed that, babA2 is not a marker for peptic ulcer disease or gastric cancer [12, 26, 33]. However, several studies have reported different results for strains isolated from Turkey or Germany [26, 34]. Our study suggests that babA2 “although quite prevalent” is associated with reduced propensity to develop GC and is thus associated with less oncogenic H. pylori. Similar results were obtained concerning babB.
Our results showed the relation of babA2, babB negative and iceA1 positive genotype and the development of cases to gastric cancer was statistically significant. Further studies are required to determine the functions of babA2 and babB and their relationship with disease outcome, and whether the presence of these alleles indicates the presence of bacteria unlikely to confer progression towards GC.
Acknowledgements
We would like to thanks , Nasarawa State University, Keffi, Marand Branch, Islamic Azad University and Erasmus MC Cancer Institute, Erasmus University of Rotterdam, The Netherlands, for their support of this research.
Reference
1. Ferlay, J., et al., Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. International journal of cancer, 2010. 127(12): p. 2893- 2917.
2. den Hoed, C.M. and E.J. Kuipers, Gastric Cancer: How Can We Reduce the Incidence of this Disease? Current Gastroenterology Reports, 2016. 18(7): p. 34.
3. Malaty, H.M., et al., Helicobacter pylori infection: genetic and environmental influences: a study of twins. Annals of internal medicine, 1994. 120(12): p. 982-986.
4. Chiurillo, M.A., et al., Genotyping of Helicobacter pylori virulence- associated genes shows high diversity of strains infecting patients in western Venezuela. International Journal of Infectious Diseases, 2013. 17(9): p. e750-e756.
5. Sahara, S., et al., Role of Helicobacter pylori cagA EPIYA motif and vacA genotypes for the development of gastrointestinal diseases in Southeast
Chapter 6
Chapter 6
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