Page 135 - Helicobacter pylori and Gastric Cancer: From Tumor microenvironment to Immunotherapy

Although, the cagA allele was observed in NUD (65.4%) cases and in PUD patients (78.9%) and in GC patients (100%), there was not statistically significant association between cagA and the gastric outcomes (P =0.134). A full overview of all virulence factors studied and their linkage to specific clinical manifestations is provided through Table 2.
Table2: Relationship between clinical outcome and status of cagE, babA2, babB, iceA1, iceA2, CagA (NUD: Non-ulcer dyspepsia, PUD: Peptic ulcer disease, GC: gastric cancer, Pv: p-value)
Genotypes Number (%) of isolates Total (n=109) p-value NUD (n=81) PUD (n=19) GC (n=9)
cagE 40 (49.4%) babA2 60 (74%) babB 53 (65.4%)
iceA1 29 (35.8%)
iceA2 11 (13.6%)
cagA 53 (65.4%)
13 (68.4%) 16 (84.2%) 12 (63.1%) 8 (42.1%) 3 (15.8%) 15 (78.9%)
8 (88.9%) 0
0
9 (100%)
0
9 (100%)
61 (55.9%) 76 (71.7%) 65 (61.3%) 46 (42.2%) 14 (13.2%) 77 (70.6%)
0.198 0.001 0.005 0.008 0.779 0.134
It is apparent from our data that, cagE, cagA and iceA1 are more common in patients with gastric cancer than in the other patient groups, whereas babA2 and babB alleles were absent in patients with GC.Combining different virulence factors allow stratification of the patient cohort with respect to patient stratification
We examined eight different combinations based on analysis of babA2, babB and iceA1 genotypes (positive and negative) in patients as a single genotype (Table 3). We were able to identify an association between these genotypes and clinical outcome. The frequency distributions of the combination genotypes of H. pylori showed the relation of babA2, babB negative and iceA1 positive genotype and the development of cases to gastric cancer was statistically significant (P <0.001) among the patient groups. But there was not statistically significant association between other genotype combination and the gastric cancer (P ≥0.113).
H-pylori pathogenicity factors H.pylori pathogenic factors
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