Page 17 - Epidemiological studies on tuberculosis control and respiratory viruses

VNTR clustering in relation to the M. tuberculosis population
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Table 2 (continued). Risk factors for clustering, with and without allowing single-locus variants to be clustered, according to lineage a
Parameter RFLP
OR (95% CI)
OR (95% CI)
no. of isolates
OR (95% CI)
OR (95% CI)
no. of isolates
Clustered Nonclustered
256 (74) 177 (23) 433
9.9 (7.4-13.3) 1
306 (89) 373 (48) 679
8.7 (6.0-12.4) 1
345
1,061 (84) 263 (19) 1,324
21.9 (17.9-26.7) 1
1,145 (90) 494 (36) 1,639
16.8 (13.5-20.8) 1
1,267 1,379 2,646
1,612 2,164 3,776
Total
785 1,130
No locus variation
Allowing SLVs to be clustered
No locus variation
Allowing SLVs to be clustered
No. (%) of VNTR clustered isolates
No. (%) of VNTR clustered isolates
Total
No. (%) of VNTR clustered isolates
No. (%) of VNTR clustered isolates
Total
Total no. of isolates in study population
Non-Euro-American lineages
Euro-American lineages
a SLV, single-locus variant (maximum threshold of one MIRU locus variation from a central strain or any other strain within the same lineage [Euro-American versus non-Euro-American lineages])
OR=odds ratio; CI=confidence interval; PTB=pulmonary tuberculosis; EPTB=extrapulmonary tuberculosis