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Chapter 476A0 5 0 100 150 200 250051 01 52 0W ith vitam in supplem entationW ithout vitam in supplem entationTim e (m in)Concentration hom ocysteine (%u00b5M )B0 5 0 100 150 200 25005 0100150200W ith vitam in supplem entationW ithout vitam in supplem entationTim e (m in)Concentration dFdU (%u00b5M )Figure 3. Plasma concentrations of homocysteine and dFdU in vitamin supplemented and unsupplemented the patients from the pharmacokinetics cohort. (A) The black line represents the supplemented arm while the dotted line represents the unsupplemented arm. Values are means %u00b1 SEM from 10 patients in each cohort. Homocysteine levels were lower in supplemented patients vs unsupplemented patients (mean 6.9 %u00b1 1.6 %u00b5M; range 6.2%u00b17.2 vs. 12.5 %u00b1 4.0 %u00b5M; range 11.7%u00b113.4; p%u00a0 <%u00a0 0.001); (B) The black line represents the supplemented arm while the dotted line represents the unsupplemented arm. Supplementation resulted in increased levels of the gemcitabine metabolite dFdU (p<0.05). Values are means %u00b1 SEM from 10 and 7 patients, respectively.