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Vitamin B12 and folic acid in advanced oesophageal and gastric cancer734due to cardiac arrhythmias likely caused by cardiac metastases and in the other case due to the occurrence of cardiac failure. These events were considered to be most likely related to cisplatin chemotherapy and underlying predisposing conditions of the patients. These three patients could not be monitored for response but were included in the intention to treat analysis for PFS and OS. Twenty patients (in both treatment groups) were treated with darbepoetin alfa for chemotherapy induced anemia [21] with a hemoglobin response in 15 of these 20 patients. Darbepoetin did not increase toxicity.Table 2. Treatment related grade 3-5 AEs per study arm. Percentages are rounded to whole numbers. For each grade 3/4/5 adverse event the maximum toxicity was noted per patient.Adverse eventSupplemented patients (n=41), n (%) Nonsupplemented patients (n=41), n (%)Grade Grade3 4 5 3 4 5Febrile neutropenia 2 (5) 1 (2)Leukopenia 9 (22) 4 (10)Trombopenia 4 (10) 3 (7) 4 (10) 1 (2)Anemia 6(15) 2 (5)Fatigue 4 (10) 10 (24)Cardiac 1 (2) 1 (2) 2 (5)Neurologic 1 (2) 2 (5) 5 (12)Ototoxicity 1 (2)Pulmonary 1 (2)Nausea 4 (10) 3 (7)Vomiting 2 (5) 2 (5)Anorexia 2 (5) 5 (12)Liver 1 (2)Diarrhea 1 (2)Pain 1 (2)Skin 1 (2)Renal/bladder 5 (12)Hemorrhage 1 (2) 1 (2) 2 (5)Infection 1 (2) 1 (2)