Page 71 - Development of Functional Scaffolds for Bone Tissue Engineering Using 3D-Bioprinting of Cells and Biomaterials - Yasaman Zamani

Figure 8. Finite element modeling of fluid shear stress distribution and magnitude as a result of fluid flow inside the 3D- printed PCL scaffolds with different void size (0.3 mm, 0.6 mm, 0.9 mm, 0.3-0.6 mm, and 0.3-0.6-0.9 mm). (a) 3D, front, back, top, and bottom view of fluid shear stress distribution and magnitude on the strands surface as a result of inlet fluid flow inside the 3D-printed scaffolds. For the homogeneous-structured scaffolds, fluid shear stress magnitude on the scaffold struts decreased with increasing scaffold void size. Fluid shear stress was rather homogeneous in all scaffolds except in the 0.3 mm void size scaffold. Fluid shear stress on the front side of the gradient-structured scaffolds was slightly lower in the upper half compared with the lower half of the scaffold while it was homogeneous on the back side. (b) Average and maximum fluid shear stress in the 0.3 mm void size scaffold were higher than in the other scaffolds.
pressure as a result of varying void sizes of scaffolds (0.3 mm, 0.6 mm, 0.9 mm, 0.3-0.6 mm, and 0.3-0.6-0.9 mm) revealed that fluid pressure magnitude decreased with increasing scaffold void size (Fig. 9a). Fluid pressure magnitude was more homogenous in scaffolds with higher void size compared to lower void size. Fluid pressure was higher in the upper half compared with the lower half of the scaffolds for both the homogenous and gradient-structured scaffolds. Average and maximum fluid pressure were highest in the 0.3 mm void size scaffold and lowest in the 0.9 mm
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