Page 62 - ADULT-ONSET ASTHMA PREDICTORS OF CLINICAL COURSE AND SEVERITY

ADULT-ONSET ASTHMA – PREDICTORS OF CLINICAL COURSE AND SEVERITY
Table E6. Threshold per marker at either 95% sensitivity or specificity in obese patients.
Table E6. Threshold per marker at either 95% sensitivity or specificity in obese patients. Table E6. Threshold per marker at either 95% sensitivity or specificity in obese patients.
Test
FTeNstO Test
Threshold
≥T8h.r6esphpobld Threshold
Sensitivity Specificity
FeNO FeNO
≥8.6 ppb
0.28 0.95 0.97 0.08
Blood Eosinophils
≥0.095 x10^9/L ≥69.5 ppb
0.97 0.08
Blood Eosinophils Blood Eosinophils
≥0.095 x10^9/L
0.25 0.95 0.97 0.25
Total IgE
≥15.5 kU/L ≥0.49 x10^9/L
0.97 0.25
Total IgE Total IgE
FeNO+blood eosinophils
FeNO+blood eosinophils FeNO+blood eosinophils
≥15.5 kU/L
0.03 0.96 0.97 0.18
Blood Eosinophils Blood Eosinophils
Total IgE
≥0.375 x10^9/L ≥0.085 x10^9/L
0.54 0.95 0.96 0.29
Total IgE Total IgE
≥1081.5 kU/L ≥15.5 kU/L
0.04 0.95 0.95 0.29
FeNO+blood eosinophils
≥15.5 kU/L
0.95 0.29
FeNO+blood eosinophils FeNO+blood eosinophils
≥0.709* ≥0.13*
0.49 0.95 0.96 0.49
≥69.5 ppb ≥8.6 ppb
0Se.9n7sitivity 0Sp.0e8cificity Sensitivity Specificity
≥69.5 ppb
0.97 0.25 0.28 0.95
≥0.49 x10^9/L ≥0.095 x10^9/L
0.28 0.95
≥0.49 x10^9/L
0.97 0.18 0.25 0.95
≥1081.5 kU/L ≥15.5 kU/L
0.25 0.95
≥0.086* ≥1081.5 kU/L
0.97 0.18
≥1081.5 kU/L
0.97 0.37 0.03 0.96
≥0.75* ≥0.086*
0.03 0.96
≥0.086*
0.42 0.95 0.97 0.37
≥0.75* ≥0.75*
0.97 0.37
Table E7. Threshold per marker at either 95% sensitivity or specificity in never smokers.
Table E7. Threshold per marker at either 95% sensitivity or specificity in never smokers. Table E7. Threshold per marker at either 95% sensitivity or specificity in never smokers.
Test
FTeNstO ≥T1h5re.1shpopldb 0Se.9n6sitivity 0Sp.4e1cificity
Threshold
Sensitivity Specificity
≥55.5 ppb
0.43 0.95
≥0.085 x10^9/L
0.96 0.29
≥15.5 kU/L ≥0.375 x10^9/L
0.95 0.29 0.54 0.95
≥0.375 x10^9/L
0.54 0.95
≥0.13* ≥1081.5 kU/L
0.96 0.49 0.04 0.95
≥1081.5 kU/L
0.04 0.95
≥0.13*
0.96 0.49
≥0.709* ≥0.709*
0.49 0.95 0.49 0.95
0.42 0.95 0.42 0.95
Test
Threshold
Sensitivity Specificity
FeNO FeNO
≥55.5 ppb ≥15.1 ppb
0.43 0.95 0.96 0.41
Blood Eosinophils
≥15.1 ppb
0.96 0.41
≥0.085 x10^9/L ≥55.5 ppb
0.96 0.29 0.43 0.95
Table E8. Threshold per marker at either 95% sensitivity or specificity in (ex)smokers.
Table E8. Threshold per marker at either 95% sensitivity or specificity in (ex)smokers. Table E8. Threshold per marker at either 95% sensitivity or specificity in (ex)smokers.
Test
Threshold
Sensitivity Specificity
FTeNstO ≥T9h.r6esphpobld 0Se.9n5sitivity 0Sp.1e4cificity Test Threshold Sensitivity Specificity
FeNO FeNO
≥63.5 ppb ≥9.6 ppb
0.39 0.95 0.95 0.14
Blood Eosinophils
≥9.6 ppb
0.95 0.14
Blood Eosinophils Blood Eosinophils
Total IgE
≥0.41 x10^9/L ≥0.085 x10^9/L
0.28 0.95 0.95 0.24
Total IgE Total IgE
≥496.5 kU/L ≥13.5 kU/L
0.11 0.95 0.95 0.28
FeNO+blood eosinophils
≥13.5 kU/L
0.95 0.28
FeNO+blood eosinophils FeNO+blood eosinophils
≥0.658* ≥0.086*
0.53 0.95 0.95 0.33
≥0.085 x10^9/L ≥63.5 ppb
0.95 0.24 0.39 0.95
≥63.5 ppb
0.39 0.95
≥0.085 x10^9/L
0.95 0.24
≥13.5 kU/L ≥0.41 x10^9/L
0.95 0.28 0.28 0.95
≥0.41 x10^9/L
0.28 0.95
≥0.086* ≥496.5 kU/L
0.95 0.33 0.11 0.95
≥496.5 kU/L
0.11 0.95
≥0.086*
0.95 0.33
≥0.658* ≥0.658*
0.53 0.95 0.53 0.95
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