Page 60 - ADULT-ONSET ASTHMA PREDICTORS OF CLINICAL COURSE AND SEVERITY
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ADULT-ONSET ASTHMA – PREDICTORS OF CLINICAL COURSE AND SEVERITY
SUPPLEMENTARY MATERIAL
Table E1. Comparison of characteristics of all adult-onset asthma patients who provided an adequate sputum sample and who did not.
No sputum
available (n=235)
Sputum available (n=336)
p-value
0.002 0.002 0.586 0.101 0.038 0.896 0.841 0.208 0.233 0.935 0.964 0.664 0.397 0.124 0.332 0.335 0.014
Age, years
Sex, female (%)
BMI, kg/m^2
Age of asthma onset
Asthma duration in years
Current smoker/ex-smoker (%)
Pack years (med)
ICS, fluticasone equivalent μg
ACQ-score 1.4 Atopy (%) 33 Nasal polyposis (%) 19 pb FEV1 % predicted 97 pb FEV1/FVC % predicted 94
±
± ±
±
± ±
±
Table E2. Multivariate logistic regression models
FeNO + Blood Eosinophils B Exp(B) 95% C.I.for EXP(B)
13
5
15 (0-10)
(4-21) (250-500) 0.8
18
12
(13-42) (18-216) 1.7 (0.10-0.30)
Fraction of exhaled NO, ppb
Total IgE, Ku/L
Blood neutrophils, x109/l
Blood eosinophils, x109/l
Data are presented as mean ± SD, percentage or median (range).
49 69 28 43
±
± ±
±
14
5
14 (0-7)
(5-18)
53 55 28 45
2 52 9 250
3 54 11 (250-750) 500 1.0 1.3 32 19 97 93 (13-38) 23 (20-143) 56 1.8 4.3 (0.08-0.28) 0.20
21 55 4.2 0.15
±
± 19 ± 12
Lower
2.81 6.78 1.96 4.31
Upper
Log FeNO (ppb)
Log Blood Eosinophils (x109/l) Constant
1.47 4.36 1.07 2.90 -3.92 0.02
Baseline characteristics + FeNO + B Exp(B) 95% C.I.for EXP(B)
Blood Eosinophils Age (years)
Female gender
FEV/VC post ≥70%
High medication use
Log FeNO (ppb)
Log Blood Eosinophils (x109/l) Constant
0.01 1.01 0.17 1.18 -1.38 0.25 0.80 2.23 1.47 4.33 0.97 2.63 -4.23 0.02
Lower Upper 0.98 1.04
0.61 2.30 0.13 0.50 1.17 4.26 2.67 7.04 1.76 3.93
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