Page 61 - ADULT-ONSET ASTHMA PREDICTORS OF CLINICAL COURSE AND SEVERITY

Table Table
E3. Threshold per marker at either 95% sensitivity or specificity in atopic patients. E3. Threshold per marker at either 95% sensitivity or specificity in atopic patients.
BIOMARKERS TO IDENTIFY SPUTUM EOSINOPHILIA IN DIFFERENT ADULT ASTHMA PHENOTYPES
Test
Threshold Sensitivity Specificity
FeNO
≥15.1 ppb 0.95 0.25 E3. Threshold per marker at either 95% sensitivity or specificity in atopic patients.
Table
Sensitivity Specificity
Test
Threshold
FeNO
≥15.1 ppb
Test
Blood Eosinophils
Threshold ≥0.085 x10^9/L
Sensitivity Specificity 0.95 0.20
FeNO
Blood Eosinophils Total IgE
Blood Eosinophils
Total IgE
FeNO+blood eosinophils
Total IgE
FeNO+blood eosinophils
FeNO+blood eosinophils
≥64.3 ppb
0.42 0.95
≥64.3 ppb
0.42 0.95 0.95 0.25
≥105.4.16 px1p0b^9/L ≥0.085 x10^9/L
0.945 0.2956 0.95 0.20
≥6245.35 pkUpb/L ≥0.46 x10^9/L ≥02.108815kxU1/0L^9/L ≥25.5 kU/L ≥0.4163*x10^9/L ≥2181 kU/L ≥205.7.514k*U/L ≥0.13*
≥2181 kU/L ≥0.714* ≥0.13*
0.4925 0.9056 0.45 0.96
0.9052 0.2906
0.95 0.06
0.495 0.9269 0.02 0.96
0.9551 0.0965 0.95 0.29 0.02 0.96 0.51 0.95 0.95 0.29
Table E4. Threshold per marker at either 95% sensitivity or specificity in non-atopic patients. ≥0.714* 0.51 0.95
Table E4. Threshold per marker at either 95% sensitivity or specificity in non-atopic patients. Test Threshold Sensitivity Specificity
Table E4. Threshold per marker at either 95% sensitivity or specificity in non-atopic patients.
FeNO ≥9.9 ppb 0.96 0.16
Test Threshold Sensitivity Specificity
≥48.5 ppb
0.44 0.95 0.96 0.16
FeNO
≥9.9 ppb
Test
Blood Eosinophils
Threshold ≥0.085 x10^9/L
Sensitivity Specificity 0.96 0.29
FeNO
Blood Eosinophils Total IgE
Blood Eosinophils
Total IgE
FeNO+blood eosinophils
Total IgE
FeNO+blood eosinophils
FeNO+blood eosinophils
≥48.5 ppb
0.44 0.95
≥90.941ppx1b0^9/L ≥0.085 x10^9/L ≥488.5.5kUpp/Lb ≥0.41 x10^9/L ≥03.8098k5Ux/1L0^9/L ≥8.5 kU/L ≥0.40186x*10^9/L ≥389 kU/L ≥80.565k6U*/L ≥0.086*
≥389 kU/L ≥0.656* ≥0.086*
0.9361 0.1965 0.96 0.29
0.4946 0.9256 0.31 0.95
0.965 0.2190
0.96 0.26
0.3916 0.9453 0.95 0.10
0.9467 0.2965 0.96 0.43 0.95 0.10 0.47 0.95 0.96 0.43
Table E5. Threshold per marker at either 95% sensitivity or specificity in non-obese patients. ≥0.656* 0.47 0.95
Table E5. Threshold per marker at either 95% sensitivity or specificity in non-obese patients.
Test Threshold Sensitivity Specificity Table E5. Threshold per marker at either 95% sensitivity or specificity in non-obese patients.
FeNO Test
≥13.1 ppb Threshold
0.95 0.33 Sensitivity Specificity
≥58.5 ppb
FeNO ≥13.1 ppb 0.95 0.33
0.42 0.95
Test Threshold Sensitivity Specificity
Blood Eosinophils
≥0.06 x10^9/L ≥58.5 ppb
0.95 0.22 0.42 0.95
FeNO
Blood Eosinophils Total IgE
Blood Eosinophils
Total IgE
FeNO+blood eosinophils
Total IgE
FeNO+blood eosinophils
FeNO+blood eosinophils
≥103.4.1 px1p0b^9/L
0.9357 0.3935
≥0.06 x10^9/L
0.95 0.22
≥5183.5 pkUpb/L ≥0.41 x10^9/L ≥05.8066kxU1/0L^9/L ≥13.5 kU/L ≥0.4112*x10^9/L ≥586 kU/L ≥103.6.58*kU/L ≥0.12*
≥586 kU/L ≥0.68* ≥0.12*
≥0.68*
0.4925 0.9353 0.37 0.95
0.9153 0.2925 0.95 0.33
0.3975 0.9456
0.13 0.95
0.9550 0.3935 0.95 0.46 0.13 0.95 0.50 0.95 0.95 0.46
0.50 0.95
3 3 3
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