Page 50 - ADULT-ONSET ASTHMA PREDICTORS OF CLINICAL COURSE AND SEVERITY

ADULT-ONSET ASTHMA – PREDICTORS OF CLINICAL COURSE AND SEVERITY
as they had test results below the lower threshold or above the upper threshold: 47% for FeNO and blood eosinophils combined (150/322), 36% for FeNO (117/326), 34% for blood eosinophils (113/331) and 25% for total IgE (83/332).
Thresholds for the separate biomarkers in di erent phenotypes are summarized in Table 3, details are shown in the appendix (Table E3-E10). Across subgroups, thresholds were rela vely stable for FeNO and the FeNO/blood eosinophils combina on model, but varied considerably for the upper levels of blood eosinophils and IgE.
Table 1. Baseline characteristics of patients who provided an adequate sputum sample (n=336).
Age, years 53 Sex, female (%) 55 BMI, kg/m^2 28 Age of asthma onset 45 Asthma duration (years) 3 Current or ex-smoker (%) 54 Pack years 1 ICS, fluticasone equivalent μg 500 ACQ-score 1.3 Atopy (%) 32 Nasal polyposis (%) 19
pb FEV1 % predicted 97
pb FEV1/FVC % predicted 93 FeNO, ppb 23 Total IgE, Ku/L 56 Blood neutrophils, x109/l 4.3 Blood eosinophils, x109/l 0.2 Sputum neutrophils, % 66.3 Sputum eosinophils, % 0.8 Data are presented as mean ± SD, percentage or median (interquartile range).
BMI, body mass index; ICS, inhaled corticosteroid; ACQ, asthma control questionnaire, FEV1, forced expiratory volume in 1 second; FVC, forced vital capacity; FeNO, fraction of exhaled nitric oxide; ppb, part per billion.
±
± ±
±
± ±
±
13
5
15 (0-10)
(0-13) (250-500) 0.8
18
12
(13-42) (18-216) 1.7 (0.1-0.3) (45.4-82.3) (0.1-6.6)
48