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ADULT-ONSET ASTHMA – PREDICTORS OF CLINICAL COURSE AND SEVERITY
Table 4. Diagnostic accuracy in in patients with different asthma phenotypes. Obesity Non-obese Obese p-value
Eosinophilia (<3%/≥3%) FeNO
Blood eosinophils
IgE
FeNO + Blood eosinophils
154/82
0.83 (0.77-0.88) 0.83 (0.77-0.89) 0.73 (0.67-0.80) 0.88 (0.83-0.93)
66/34 0.90 0.78 (0.68-0.89) 0.46 0.82 (0.73-0.91) 0.82 0.59 (0.47-0.70) 0.03 0.85 (0.76-0.93) 0.55
Atopy Non-atopic Atopic
Eosinophilia (<3%/≥3%) FeNO
Blood eosinophils
IgE
FeNO + Blood eosinophils
153/74
0.83 (0.77-0.89) 0.83 (0.77-0.89) 0.75 (0.68-0.82) 0.88 (0.82-0.92)
67/42 0.28 0.78 (0.69-0.88) 0.40 0.83 (0.74-0.91) 0.99 0.57 (0.46-0.68) <0.01 0.85 (0.77-0.93) 0.63
Asthma severity Mild-moderate Severe asthma
Eosinophilia (<3%/≥3%) FeNO
Blood eosinophils
IgE
FeNO + Blood eosinophils
161/58
0.81 (0.74-0.88) 0.82 (0.76-0.89) 0.68 (0.61-0.76) 0.86 (0.81-0.92)
58/57 <0.01 0.83 (0.75-0.91) 0.67
0.80 (0.72-0.89) 0.73 0.66 (0.56-0.76) 0.70 0.85 (0.78-0.92) 0.81
Smoking status Never smoker Ex- or current smoker
Eosinophilia (<3%/≥3%) FeNO
Blood eosinophils
IgE
FeNO + Blood eosinophils
103/51
0.84 (0.77-0.90) 0.86 (0.79-0.93) 0.64 (0.55-0.73) 0.88 (0.82-0.94)
117/65 0.62 0.81 (0.73-0.88) 0.52
0.80 (0.73-0.87) 0.23 0.74 (0.66-0.81) 0.13 0.86 (0.80-0.92) 0.64
AUC and 95% confidence interval are given per biomarker in every subgroup. The difference between the AUC’s for every biomarker is compared within the separate subgroups, result depicted as p-value. AUC, area under the curve; FeNO, fraction of exhaled nitric oxide.
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