Page 84 - THE EVOLUTION OF EARLY ARTHRITIS AND CARDIOVASCULAR RISK Samina A. Turk

CHAPTER 4
Table 5. Body composition indices of non-arthritis controls (females n=880, males n=388), and the differences of these indices with early arthritis patients (females n=220, males n=97), stratified for gender
BMI 27.1
ALMI 7.0
FMI 26.6
Android to 0.5 gynoid fat
mass ratio
Body fat% 39.8
% of fat 49.4 distributed
to the trunk
Obese 38.4
Low muscle 1.3 mass for
age
(4.7) 1.0
(0.26-1.70) 0.008*
(0.8) -0.3
(-0.44- -0.19) <0.001*
(4.6) 1.1
(0.38-1.78) 0.003*
(0.2) <0.1
(-0.04-0.00) 0.102
(6.4) 0.9
(-0.05-1.92) 0.062
(6.5) 2.8
(1.83-3.75) <0.001*
27.4 (3.7) -0.3
(-1.11-0.61)
8.6 (1.0) -0.6
(-0.83- -0.39)
27.4 (3.6) -0.6
(-1.45-0.23)
0.8 (0.2) -0.1
(-0.09- -0.01)
30.7 (5.5) -0.8
(-2.07-0.47)
57.6 (5.6) 1.2
(-0.11-2.47)
0.573
0.001*
0.154
0.029
0.216
0.074
0.324
0.002*
Mean values Differences for female for control arthritis patients, B or OR females (CI) and p-value
Mean values for control males
Differences for male arthritis patients, B or OR (CI) and p-value
1.3 58 0.8
(0.98-1.78) 0.068
(0.51-1.25)
4.2 1.5 5.7
(1.78-9.72) 0.001*
(1.94-16.91)
Results are expressed as mean (SD) or percentages and as beta (B) or odds ratio (OR) with a 95%-confidence interval (CI) and a p-value.
ALMI: appendicular lean mass index, BMI: body mass index, FMI: fat mass index, n=number, RA: rheumatoid arthritis, SD: standard deviation, %: percentages *significant results at the 0.05 false discovery rate for 18 tests, between arthritis patients and non-arthritis controls
Lipid levels and blood pressure and the association with body composition in early arthritis patients.
Forty-six patients were on statins and 87 on antihypertensives and were excluded from these analyzes. An unfavorable body composition (higher FMI, more fat distributed to the trunk and more android fat) was associated with an unfavorable lipid profile (see S1 Table). No association between ALMI and lipid levels was found.
A higher FMI and more fat distributed to the trunk were associated with a higher systolic and diastolic blood pressure. In females a higher ALMI was also related with higher blood pressures.
82